Cancer invasion and metastasis: interacting ecosystems

• Type: Another Publication in an International Scientific Journal
• Date: 2009

Authors

Mareel, M (Author) Other; Oliveira, MJ (Author) FMUP; Madani, I (Author) Other

Journal

Title: Virchows Archiv

Vol. 454

Pages: 599-622

ISSN: 0945-6317

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 54 Citations

Scopus - 36 Citations

Other information

Authenticus ID: P-003-JZR

DOI: 10.1007/s00428-009-0784-0

Abstract (EN): Malignant tumors invade and metastasize. They consist of cancer cells, evolving through genetic and epigenetic modulation, mixed with tumor-associated host cells, emerging from resident or bone marrow-derived precursors. These cells establish ecosystems to activate cellular programs for local invasion and distant metastasis. Characteristic of such malignancy-related activities is communication inside ecosystems between cells, ligands, receptor protein complexes, and signaling pathways as well as between ecosystems comprising the primary tumor, lymph node and distant metastasis, bone marrow and blood and lymph circulation. Complexity is another characteristic, resulting from: heterogeneity of the cell populations; the numbers of promoter and suppressor genes, their levels of regulation, and the pleiotropic activities of their products; biological redundancy of the molecular mechanisms underpinning invasion-related activities. Clinical attention is paid to putative new targets, namely host cells, individual molecules and their signaling pathways, as well as the effects of current treatment on invasion and metastasis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 24