ON THE PARAMETERS ESTIMATION OF HIV DYNAMIC MODELS

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Rocha, D (Author) Other; Gouveia, S (Author) Other; Pinto, C (Author) Other; Scotto, M (Author) Other; João Tavares (Author) FCUP; Valadas, E (Author) Other; Caldeira, LF (Author) Other

Journal

Title: Revstat Statistical Journal

Vol. 17

Pages: 209-222

ISSN: 1645-6726

Publisher: Instituto Nacional De Estatistica

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00Q-JE7

Abstract (EN): This work proposes an estimation method to obtain the optimal parameter estimates of a mathematical model, from a set of CD4(+)T values collected in a HIV patient. To this end, the following scheme is adopted: the first step consists in selecting an initial estimate for the model's parameters as that having minimum square error, from a set of uniform randomly generated candidates. In the second step, the initial solution is refined by an optimization algorithm with constraints and bounds (imposed by physiology), resulting on the optimal estimate. The proposed method is validated through a simulation study and illustrated with an application to a real data set of CD4(+)T cells counts for several HIV patients.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14