Hydroxyapatite, Biocompatible Glass and Silicon-based Bone Substitute, Production Process and Applications of Therof

• Type: Patent
• Date: 2009

Authors

José Domingos da Silva Santos (Author) FEUP; M. A. Lopes (Author) FEUP; Cláudia M. Botelho (Author) FEUP

Patent

No. WO2009/126054A1

Scope: International

Scientific classification

FOS: Engineering and technology > Medical engineering

Other information

Abstract (EN): “Hydroxyapatite, biocompatible glass and silicon-based Bone substitute, production process and aplications of therof” The disclosed invention is based on hydroxyapatite, biocompatible glass and silicon, aiming to develop an improved bone substitute, which presents higher mechanical resistance, bioactivity and osteoregeneration, and susceptible of being used in several medical and surgical fields, with application in the treatment of bone disease caused by trauma or genetic factors, as osteoconductive support for cellular growth. The abovementioned bone substitute comprises hydroxyapatite, a biocompatible glass of the P2O5-CaO system in a percentage up to 10wt% relatively to the hydroxyapatite weight, and a silicon source in a concentration up to 10wt% relatively to hydroxyapatite and biocompatible glass weight. The preparation process of the disclosed bone substitute consists of liquid phase sintering of a homogeneous mixture of hydroxyapatite, biocompatible glass and silicon source preferentially within a temperature range of 1100-1350ºC, which allows glass melting and fusion throughout hydroxyapatite structure leading to the occurrence of several ionic substitutions.

Language: English

Type (Professor's evaluation): Scientific

Reference: PCT/Pt2008/000014

No. of pages: 27