Bone remodeling: an improved spatiotemporal mathematical model

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Madalena M. A. Peyroteo (Author) Other; Jorge Belinha (Author) Other; Lúcia Maria Dinis (Author) Other; Renato Natal Jorge (Author) FEUP

Journal

Title: Archive of Applied Mechanics

Vol. 90 No. 3

Pages: 635-649

ISSN: 0939-1533

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-00R-DFJ

DOI: 10.1007/s00419-019-01631-z

Abstract (EN): Bone remodeling is a key process in vertebrate organisms, since it is responsible for maintaining skeleton's integrity. However, in some pathological conditions, such as osteoporosis or Paget's disease, bone's function becomes compromised. To gain a better understanding about these conditions, bone remodeling has become a determinant subject of research. Remodeling implies resorption of bone by osteoclasts followed by formation of new tissue by osteoblasts. The interaction between these two bone cells is reproduced in this work by extending the bone remodeling model of Ayati et al. (Biol Direct 5:28, 2010. ). Also, for the first time, a discrete numerical method-finite element method (FEM)-is applied to solve the remodeling equations and analyze the results. A single cycle of remodeling is simulated using a two-dimensional bone patch. Results show that the developed mathematical model is able to correlate bone cell dynamics with different phases of the remodeling process, allowing to obtain the transient spatial distribution of bone's apparent density along time. Thus, the presented model reveals itself as a successful approach, producing an accurate temporal-spatial evolution of bone cells during an event of bone remodeling.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15