Comparison of the Nancy Index With Continuous Geboes Score: Histological Remission and Response in Ulcerative Colitis

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Magro F (Author) FMUP; Lopes, J (Author) Other; Borralho, P (Author) Other; Dias C (Author) FMUP; Afonso, J (Author) Other; Ministro, P (Author) Other; Santiago, M (Author) Other; Geboes, K (Author) Other; Carneiro F (Author) FMUP; Lopes, S (Author) Other; Coelho, R (Author) Other; Cotter, J (Author) Other; de Castro, FD (Author) Other; de Sousa, HT (Author) Other; Salgado, M (Author) Other; Andrade, P (Author) Other; Vieira, A (Author) Other; Figueiredo, P (Author) Other; Caldeira, P (Author) Other; Sousa, A (Author) Other; Duarte, M (Author) Other; Ávila, F (Author) Other; Silva, J (Author) Other; Moleiro, J (Author) Other; Mendes, S (Author) Other; Giestas, S (Author) Other; Sousa, P (Author) Other; Gonçalves, R (Author) Other; Gonçalves, BM (Author) Other; Oliveira, AM (Author) Other; Chagas, C (Author) Other; Portuguese IBD Study Group [GEDII], (Author) Other

Journal

Title: Journal of Crohn's and Colitis

Vol. 14

Pages: 1021-1025

ISSN: 1873-9946

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 18 Citations

Other information

Authenticus ID: P-00S-HJY

DOI: 10.1093/ecco-jcc/jjaa010

Abstract (EN): Background and Aims: Evidence has been supporting that histological activity of ulcerative colitis [UC] has relevance for the prediction of clinical outcomes in UC patients, such as clinical relapse. In this study, we aimed to compare two histological indexes-the continuous Geboes score [GS] and the Nancy index [NI] -regarding their definitions of histological remission and response, and to determine the ability of faecal calprotectin [FC] levels to discriminate between these histological statuses according to the NI. Methods: A large cohort of UC patients [N = 422] who were previously enrolled in other studies was analysed. Results: GS and NI were shown to be strongly correlated [correlation coefficient: 0.882, p<0.001], indicating high accordance in the classification of patients as having/not having histological remission and response. FC levels moderately correlated with NI regarding these histological statuses [correlation coefficient: 0.481, p<0.001], moderately predicted the absence of remission defined by NI >0 {area under the curve (AUC) 0.667 (95% confidence interval [CI] 0.609-0.724)}, and were good predictors of the absence of histological response defined by NI >1 (AUC 0.825 [95% CI 0.777-0.872]). The optimal FC cut-offs determined to predict the NI-defined histological remission and response were 91 mu g/g and 106 mu g/g, when maximising the negative predictive value [NPV]. Conclusions: Due to the higher applicability of the NI, this study encourages the systematic use of this histological index to assess histological remission and response in UC patients.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5