Cortical maturation in fetuses referred for isolated' mild ventriculomegaly: a longitudinal ultrasound assessment

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Miguelote, RF (Author) Other; Vides, B (Author) Other; Santos RF (Author) FMUP; Palha, JA (Author) Other; matias, a (Author) FMUP; Sousa, N (Author) Other

Journal

Title: Prenatal Diagnosis

Vol. 32

Pages: 1273-1281

ISSN: 0197-3851

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 12 Citations

Other information

Authenticus ID: P-002-2WB

DOI: 10.1002/pd.3992

Abstract (EN): Objectives To compare cortical maturation between fetuses with isolated mild ventriculomegaly (IMV) and healthy fetuses, and to explore its potential prognostic value in IMV. Methods This prospective study quantified cortical maturation by ultrasound in 24 fetuses with IMV and 46 healthy fetuses. Depth and grading the developmental pattern of the parieto-occipital fissure (POF), calcarine fissure (CF) and sylvian fissure, and grading the Sylvian fissure operculization at 2325, 2728 and 3132?weeks gestation were determined. Results At 2325 and 2728 gestational weeks, POF and CF mean depths were statistically lower in the IMV group. The POF and CF depth distribution had a normal distribution in the control group but displayed a bimodal distribution in the IMV group. IMV with progression of ventricular dilatation showed mean depth of CF lower than IMV in which ventriculomegaly regressed or remained stable. The sensitivity, specificity, positive predictive value and negative predictive value of a CF depth below the fifth percentile to predict progression of ventricular dilatation were, at 28?weeks, 100%, 88%, 67% and 100%, respectively. Conclusions Cortical fissure assessment by ultrasound allowed the differentiation of a subgroup of IMV fetuses with a higher risk of progression of ventricular dilatation. (c) 2012 John Wiley & Sons, Ltd.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9