Second level screening test for chromosomal abnormalities in the first trimester: The role of ductus venosus

• Type: Article in International Conference Proceedings Book
• Date: 2000

Authors

matias, a (Author) FMUP; Montenegro, N (Author) Other; Areias JC (Author) FMUP; Nicolaides, K (Author) Other

Conference proceedings International

Title: FETUS AS A PATIENT

Pages: 35-41

16th International Congress on The Fetus as a Patient

FIUGGI, ITALY, APR 01-05, 2000

Indexing

ISI Web of Knowledge - 0 Citations

Other information

Authenticus ID: P-001-1GC

Abstract (EN): In this study we investigated the possible contribution of Doppler assessment of ductus venosus (DV) blood flow in screening for chromosomal abnormalities at 11-14 weeks of gestation. DV blood flow waveforms were obtained immediately before fetal karyotyping in 515 consecutive singleton pregnancies at 11-14 weeks. In all cases screening for chromosomal defects was pet-formed by a combination of maternal age and fetal nuchal translucency thickness. There were 69 chromosomal defects (43 trisomies 21; 12 trisomies 18; seven trisomies 13, four Turner syndromes and three triploidies). In 62/69 (89.8%) cases there was reverse or absent flow during atrial contraction. Abnormal ductal flow was also observed in 17/446 (3.8%) chromosomally normal fetuses, seven of which had cardiac defects. We suggest that assessment of DV blood flow in pregnancies considered to be at high-risk for chromosomal defects may result in a major reduction in the need for invasive testing with only a small decrease in sensitivity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7