Comparative Cr, As and CCA induced Cytostaticity in mice kidney: A contribution to assess CCA toxicity

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Matos, RC (Author) Other; Oliveira, H (Author) Other; Fonseca, HMAC (Author) Other; Morais, S (Author) Other; Sharma, B (Author) Other; Santos, C (Author) FCUP; Pereira, MD (Author) Other

Journal

Title: Environmental Toxicology and Pharmacology

Vol. 73

ISSN: 1382-6689

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 12 Citations

Other information

Authenticus ID: P-00R-8VA

DOI: 10.1016/j.etap.2019.103297

Abstract (EN): CCA (Chromium Copper Arsenate) treated wood, widely used in outdoor residential structures and playgrounds, poses considerable dangers of leaching of its components to the environment. In this study, mouse kidney samples were used to evaluate the effects of CCA, chromium trioxide (CrO3) and arsenic pentoxide (As2O5) on cell pathophysiology by flow cytometry. Samples were collected after 14, 24, 48 and 96 h of animal exposure. While Cr had no statistically significant cytostatic effects, As2O5 induced a S-phase delay in animals exposed for 24 h, and over time a G0/G1 phase blockage. The effects of CCA in S-phase were similar, but more severe than those of As2O5. Since environmental and public health hazards due to the long durability of CCA-treated wood products, these data confirm that CCA has profoundly toxic effects on cell cycle, distinct from the compounds themselves. These cytostatic effects support cell cycle dynamics as a valuable endpoint to assess the toxicity of remaining CCA-treated infrastructures, and the expected increased waste stream over the coming decades.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7