An integrated encyclopedia of DNA elements in the human genome

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Lochovsky, L (Author) Other; Min, R (Author) Other; Mu, XMJ (Author) Other; Rozowsky, J (Author) Other; Yan, KK (Author) Other; Yip, KY (Author) Other; Birney, E (Author) Other; Dunham, I (Author) Other; Kundaje, A (Author) Other; Aldred, SF (Author) Other; Collins, PJ (Author) Other; Davis, C (Author) Other; Doyle, F (Author) Other; Epstein, CB (Author) Other; Frietze, S (Author) Other; Harrow, J (Author) Other; Kaul, R (Author) Other; Khatun, J (Author) Other; Lajoie, BR (Author) Other; Landt, SG (Author) Other; Lee, BK (Author) Other; Pauli, F (Author) Other; Rosenbloom, KR (Author) Other; Sabo, P (Author) Other; Safi, A (Author) Other; Sanyal, A (Author) Other; Shoresh, N (Author) Other; Simon, JM (Author) Other; Song, L (Author) Other; Trinklein, ND (Author) Other; Altshuler, RC (Author) Other; Birney, E (Author) Other; Brown, JB (Author) Other; Cheng, C (Author) Other; Djebali, S (Author) Other; Dong, XJ (Author) Other; Dunham, I (Author) Other; Ernst, J (Author) Other; Furey, TS (Author) Other; Gerstein, M (Author) Other; Giardine, B (Author) Other; Greven, M (Author) Other; Hardison, RC (Author) Other; Harris, RS (Author) Other; Herrero, J (Author) Other; Hoffman, MM (Author) Other; Iyer, S (Author) Other; Kellis, M (Author) Other; Khatun, J (Author) Other; Kheradpour, P (Author) Other; Kundaje, A (Author) Other; Lassmann, T (Author) Other; Li, QH (Author) Other; Lin, X (Author) Other; Marinov, GK (Author) Other; Merkel, A (Author) Other; Mortazavi, A (Author) Other; Parker, SCJ (Author) Other; Reddy, TE (Author) Other; Rozowsky, J (Author) Other; Schlesinger, F (Author) Other; Thurman, RE (Author) Other; Wang, J (Author) Other; Ward, LD (Author) Other; Whitfield, TW (Author) Other; Wilder, SP (Author) Other; Wu, W (Author) Other; Xi, HLS (Author) Other; Yip, KY (Author) Other; Zhuang, JL (Author) Other; Bernstein, BE (Author) Other; Birney, E (Author) Other; Dunham, I (Author) Other; Green, ED (Author) Other; Gunter, C (Author) Other; Snyder, M (Author) Other; Pazin, MJ (Author) Other; Lowdon, RF (Author) Other; Dillon, LAL (Author) Other; Adams, LB (Author) Other; Kelly, CJ (Author) Other; Zhang, J (Author) Other; Wexler, JR (Author) Other; Green, ED (Author) Other; Good, PJ (Author) Other; Feingold, EA (Author) Other; Bernstein, BE (Author) Other; Birney, E (Author) Other; Crawford, GE (Author) Other; Dekker, J (Author) Other; Elnitski, L (Author) Other; Farnham, PJ (Author) Other; Gerstein, M (Author) Other; Giddings, MC (Author) Other; Gingeras, TR (Author) Other; Green, ED (Author) Other; Guigo, R (Author) Other; Hardison, RC (Author) Other; Hubbard, TJ (Author) Other; Kellis, M (Author) Other; Kent, WJ (Author) Other; Lieb, JD (Author) Other; Margulies, EH (Author) Other; Myers, RM (Author) Other; Snyder, M (Author) Other; Stamatoyannopoulos, JA (Author) Other; Tenenbaum, SA (Author) Other; Weng, ZP (Author) Other; White, KP (Author) Other; Wold, B (Author) Other; Khatun, J (Author) Other; Yu, Y (Author) Other; Wrobel, J (Author) Other; Risk, BA (Author) Other; Gunawardena, HP (Author) Other; Kuiper, HC (Author) Other; Maier, CW (Author) Other; Xie, L (Author) Other; Chen, X (Author) Other; Giddings, MC (Author) Other; Bernstein, BE (Author) Other; Epstein, CB (Author) Other; Shoresh, N (Author) Other; Ernst, J (Author) Other; Kheradpour, P (Author) Other; Mikkelsen, TS (Author) Other; Gillespie, S (Author) Other; Goren, A (Author) Other; Ram, O (Author) Other; Zhang, XL (Author) Other; Wang, L (Author) Other; Issner, R (Author) Other; Coyne, MJ (Author) Other; Durham, T (Author) Other; Ku, M (Author) Other; Truong, T (Author) Other; Ward, LD (Author) Other; Altshuler, RC (Author) Other; Eaton, ML (Author) Other; Kellis, M (Author) Other; Djebali, S (Author) Other; Davis, CA (Author) Other; Merkel, A (Author) Other; Dobin, A (Author) Other; Lassmann, T (Author) Other; Mortazavi, A (Author) Other; Tanzer, A (Author) Other; Lagarde, J (Author) Other; Lin, W (Author) Other; Schlesinger, F (Author) Other; Xue, CH (Author) Other; Marinov, GK (Author) Other; Khatun, J (Author) Other; Williams, BA (Author) Other; Zaleski, C (Author) Other; Rozowsky, J (Author) Other; Roeder, M (Author) Other; Kokocinski, F (Author) Other; Abdelhamid, RF (Author) Other; Alioto, T (Author) Other; Antoshechkin, I (Author) Other; Baer, MT (Author) Other; Batut, P (Author) Other; Bell, I (Author) Other; Bell, K (Author) Other; Chakrabortty, S (Author) Other; Chen, X (Author) Other; Chrast, J (Author) Other; Curado, J (Author) Other; Derrien, T (Author) Other; Drenkow, J (Author) Other; Dumais, E (Author) Other; Dumais, J (Author) Other; Duttagupta, R (Author) Other; Fastuca, M (Author) Other; Fejes Toth, K (Author) Other; Ferreira, P (Author) Other; Foissac, S (Author) Other; Fullwood, MJ (Author) Other; Gao, H (Author) Other; Gonzalez, D (Author) Other; Gordon, A (Author) Other; Gunawardena, HP (Author) Other; Howald, C (Author) Other; Jha, S (Author) Other; Johnson, R (Author) Other; Kapranov, P (Author) Other; King, B (Author) Other; Kingswood, C (Author) Other; Li, GL (Author) Other; Luo, OJ (Author) Other; Park, E (Author) Other; Preall, JB (Author) Other; Presaud, K (Author) Other; Ribeca, P (Author) Other; Risk, BA (Author) Other; Robyr, D (Author) Other; Ruan, XA (Author) Other; Sammeth, M (Author) Other; Sandhu, KS (Author) Other; Schaeffer, L (Author) Other; See, LH (Author) Other; Shahab, A (Author) Other; Skancke, J (Author) Other; Suzuki, AM (Author) Other; Takahashi, H (Author) Other; Tilgner, H (Author) Other; Trout, D (Author) Other; Walters, N (Author) Other; Wang, HE (Author) Other; Wrobel, J (Author) Other; Yu, YB (Author) Other; Hayashizaki, Y (Author) Other; Harrow, J (Author) Other; Gerstein, M (Author) Other; Hubbard, TJ (Author) Other; Reymond, A (Author) Other; Antonarakis, SE (Author) Other; Hannon, GJ (Author) Other; Giddings, MC (Author) Other; Ruan, YJ (Author) Other; Wold, B (Author) Other; Carninci, P (Author) Other; Guigo, R (Author) Other; Gingeras, TR (Author) Other; Rosenbloom, KR (Author) Other; Sloan, CA (Author) Other; Learned, K (Author) Other; Malladi, VS (Author) Other; Wong, MC (Author) Other; Barber, G (Author) Other; Cline, MS (Author) Other; Dreszer, TR (Author) Other; Heitner, SG (Author) Other; Karolchik, D (Author) Other; Kent, WJ (Author) Other; Kirkup, VM (Author) Other; Meyer, LR (Author) Other; Long, JC (Author) Other; Maddren, M (Author) Other; Raney, BJ (Author) Other; Furey, TS (Author) Other; Song, LY (Author) Other; Grasfeder, LL (Author) Other; Giresi, PG (Author) Other; Lee, BK (Author) Other; Battenhouse, A (Author) Other; Sheffield, NC (Author) Other; Simon, JM (Author) Other; Showers, KA (Author) Other; Safi, A (Author) Other; London, D (Author) Other; Bhinge, AA (Author) Other; Shestak, C (Author) Other; Schaner, MR (Author) Other; Kim, SK (Author) Other; Zhang, ZZZ (Author) Other; Mieczkowski, PA (Author) Other; Mieczkowska, JO (Author) Other; Liu, Z (Author) Other; McDaniell, RM (Author) Other; Ni, YY (Author) Other; Rashid, NU (Author) Other; Kim, MJ (Author) Other; Adar, S (Author) Other; Zhang, ZC (Author) Other; Wang, TY (Author) Other; Winter, D (Author) Other; Keefe, D (Author) Other; Birney, E (Author) Other; Iyer, VR (Author) Other; Lieb, JD (Author) Other; Crawford, GE (Author) Other; Li, GL (Author) Other; Sandhu, KS (Author) Other; Zheng, MZ (Author) Other; Wang, P (Author) Other; Luo, OJ (Author) Other; Shahab, A (Author) Other; Fullwood, MJ (Author) Other; Ruan, XA (Author) Other; Ruan, YJ (Author) Other; Myers, RM (Author) Other; Pauli, F (Author) Other; Williams, BA (Author) Other; Gertz, J (Author) Other; Marinov, GK (Author) Other; Reddy, TE (Author) Other; Vielmetter, J (Author) Other; Partridge, EC (Author) Other; Trout, D (Author) Other; Varley, KE (Author) Other; Gasper, C (Author) Other; Bansal, A (Author) Other; Pepke, S (Author) Other; Jain, P (Author) Other; Amrhein, H (Author) Other; Bowling, KM (Author) Other; Anaya, M (Author) Other; Cross, MK (Author) Other; King, B (Author) Other; Muratet, MA (Author) Other; Antoshechkin, I (Author) Other; Newberry, KM (Author) Other; Mccue, K (Author) Other; Nesmith, AS (Author) Other; Fisher Aylor, KI (Author) Other; Pusey, B (Author) Other; DeSalvo, G (Author) Other; Parker, SL (Author) Other; Balasubramanian, S (Author) Other; Davis, NS (Author) Other; Meadows, SK (Author) Other; Eggleston, T (Author) Other; Gunter, C (Author) Other; Newberry, JS (Author) Other; Levy, SE (Author) Other; Absher, DM (Author) Other; Mortazavi, A (Author) Other; Wong, WH (Author) Other; Wold, B (Author) Other; Blow, MJ (Author) Other; Visel, A (Author) Other; Pennachio, LA (Author) Other; Elnitski, L (Author) Other; Margulies, EH (Author) Other; Parker, SCJ (Author) Other; Petrykowska, HM (Author) Other; Abyzov, A (Author) Other; Aken, B (Author) Other; Barrell, D (Author) Other; Barson, G (Author) Other; Berry, A (Author) Other; Bignell, A (Author) Other; Boychenko, V (Author) Other; Bussotti, G (Author) Other; Chrast, J (Author) Other; Davidson, C (Author) Other; Derrien, T (Author) Other; Despacio Reyes, G (Author) Other; Diekhans, M (Author) Other; Ezkurdia, I (Author) Other; Frankish, A (Author) Other; Gilbert, J (Author) Other; Gonzalez, JM (Author) Other; Griffiths, E (Author) Other; Harte, R (Author) Other; Hendrix, DA (Author) Other; Howald, C (Author) Other; Hunt, T (Author) Other; Jungreis, I (Author) Other; Kay, M (Author) Other; Khurana, E (Author) Other; Kokocinski, F (Author) Other; Leng, J (Author) Other; Lin, MF (Author) Other; Loveland, J (Author) Other; Lu, Z (Author) Other; Manthravadi, D (Author) Other; Mariotti, M (Author) Other; Mudge, J (Author) Other; Mukherjee, G (Author) Other; Notredame, C (Author) Other; Pei, BK (Author) Other; Rodriguez, JM (Author) Other; Saunders, G (Author) Other; Sboner, A (Author) Other; Searle, S (Author) Other; Sisu, C (Author) Other; Snow, C (Author) Other; Steward, C (Author) Other; Tanzer, A (Author) Other; Tapanari, E (Author) Other; Tress, ML (Author) Other; van Baren, MJ (Author) Other; Walters, N (Author) Other; Washietl, S (Author) Other; Wilming, L (Author) Other; Zadissa, A (Author) Other; Zhang, ZD (Author) Other; Brent, M (Author) Other; Haussler, D (Author) Other; Kellis, M (Author) Other; Valencia, A (Author) Other; Gerstein, M (Author) Other; Reymond, A (Author) Other; Guigo, R (Author) Other; Harrow, J (Author) Other; Hubbard, TJ (Author) Other; Landt, SG (Author) Other; Frietze, S (Author) Other; Abyzov, A (Author) Other; Addleman, N (Author) Other; Alexander, RP (Author) Other; Auerbach, RK (Author) Other; Balasubramanian, S (Author) Other; Bettinger, K (Author) Other; Bhardwaj, N (Author) Other; Boyle, AP (Author) Other; Cao, AR (Author) Other; Cayting, P (Author) Other; Charos, A (Author) Other; Cheng, Y (Author) Other; Cheng, C (Author) Other; Eastman, C (Author) Other; Euskirchen, G (Author) Other; Fleming, JD (Author) Other; Grubert, F (Author) Other; Habegger, L (Author) Other; Hariharan, M (Author) Other; Harmanci, A (Author) Other; Iyengar, S (Author) Other; Jin, VX (Author) Other; Karczewski, KJ (Author) Other; Kasowski, M (Author) Other; Lacroute, P (Author) Other; Lam, H (Author) Other; Lamarre Vincent, N (Author) Other; Leng, J (Author) Other; Lian, J (Author) Other; Lindahl Allen, M (Author) Other; Min, RQ (Author) Other; Miotto, B (Author) Other; Monahan, H (Author) Other; Moqtaderi, Z (Author) Other; Mu, XMJ (Author) Other; O'Geen, H (Author) Other; Ouyang, ZQ (Author) Other; Patacsil, D (Author) Other; Pei, BK (Author) Other; Raha, D (Author) Other; Ramirez, L (Author) Other; Reed, B (Author) Other; Rozowsky, J (Author) Other; Sboner, A (Author) Other; Shi, MY (Author) Other; Sisu, C (Author) Other; Slifer, T (Author) Other; Witt, H (Author) Other; Wu, LF (Author) Other; Xu, XQ (Author) Other; Yan, KK (Author) Other; Yang, XQ (Author) Other; Yip, KY (Author) Other; Zhang, ZD (Author) Other; Struhl, K (Author) Other; Weissman, SM (Author) Other; Gerstein, M (Author) Other; Farnham, PJ (Author) Other; Snyder, M (Author) Other; Tenenbaum, SA (Author) Other; Penalva, LO (Author) Other; Doyle, F (Author) Other; Karmakar, S (Author) Other; Landt, SG (Author) Other; Bhanvadia, RR (Author) Other; Choudhury, A (Author) Other; Domanus, M (Author) Other; Ma, LJ (Author) Other; Moran, J (Author) Other; Patacsil, D (Author) Other; Slifer, T (Author) Other; Victorsen, A (Author) Other; Yang, XQ (Author) Other; Snyder, M (Author) Other; White, KP (Author) Other; Auer, T (Author) Other; Centanin, L (Author) Other; Eichenlaub, M (Author) Other; Gruhl, F (Author) Other; Heermann, S (Author) Other; Hoeckendorf, B (Author) Other; Inoue, D (Author) Other; Kellner, T (Author) Other; Kirchmaier, S (Author) Other; Mueller, C (Author) Other; Reinhardt, R (Author) Other; Schertel, L (Author) Other; Schneider, S (Author) Other; Sinn, R (Author) Other; Wittbrodt, B (Author) Other; Wittbrodt, J (Author) Other; Weng, ZP (Author) Other; Whitfield, TW (Author) Other; Wang, J (Author) Other; Collins, PJ (Author) Other; Aldred, SF (Author) Other; Trinklein, ND (Author) Other; Partridge, EC (Author) Other; Myers, RM (Author) Other; Dekker, J (Author) Other; Jain, G (Author) Other; Lajoie, BR (Author) Other; Sanyal, A (Author) Other; Balasundaram, G (Author) Other; Bates, DL (Author) Other; Byron, R (Author) Other; Canfield, TK (Author) Other; Diegel, MJ (Author) Other; Dunn, D (Author) Other; Ebersol, AK (Author) Other; Frum, T (Author) Other; Garg, K (Author) Other; Gist, E (Author) Other; Hansen, RS (Author) Other; Boatman, L (Author) Other; Haugen, E (Author) Other; Humbert, R (Author) Other; Jain, G (Author) Other; Johnson, AK (Author) Other; Johnson, EM (Author) Other; Kutyavin, TV (Author) Other; Lajoie, BR (Author) Other; Lee, K (Author) Other; Lotakis, D (Author) Other; Maurano, MT (Author) Other; Neph, SJ (Author) Other; Neri, FV (Author) Other; Nguyen, ED (Author) Other; Qu, HZ (Author) Other; Reynolds, AP (Author) Other; Roach, V (Author) Other; Rynes, E (Author) Other; Sabo, P (Author) Other; Sanchez, ME (Author) Other; Sandstrom, RS (Author) Other; Sanyal, A (Author) Other; Shafer, AO (Author) Other; Stergachis, AB (Author) Other; Thomas, S (Author) Other; Thurman, RE (Author) Other; Vernot, B (Author) Other; Vierstra, J (Author) Other; Vong, S (Author) Other; Wang, H (Author) Other; Weaver, MA (Author) Other; Yan, YQ (Author) Other; Zhang, MH (Author) Other; Akey, JM (Author) Other; Bender, M (Author) Other; Dorschner, MO (Author) Other; Groudine, M (Author) Other; MacCoss, MJ (Author) Other; Navas, P (Author) Other; Stamatoyannopoulos, G (Author) Other; Kaul, R (Author) Other; Dekker, J (Author) Other; Stamatoyannopoulos, JA (Author) Other; Dunham, I (Author) Other; Beal, K (Author) Other; Brazma, A (Author) Other; Flicek, P (Author) Other; Herrero, J (Author) Other; Johnson, N (Author) Other; Keefe, D (Author) Other; Lukk, M (Author) Other; Luscombe, NM (Author) Other; Sobral, D (Author) Other; Vaquerizas, JM (Author) Other; Wilder, SP (Author) Other; Batzoglou, S (Author) Other; Sidow, A (Author) Other; Hussami, N (Author) Other; Kyriazopoulou Panagiotopoulou, S (Author) Other; Libbrecht, MW (Author) Other; Schaub, MA (Author) Other; Kundaje, A (Author) Other; Hardison, RC (Author) Other; Miller, W (Author) Other; Giardine, B (Author) Other; Harris, RS (Author) Other; Wu, W (Author) Other; Bickel, PJ (Author) Other; Banfai, B (Author) Other; Boley, NP (Author) Other; Brown, JB (Author) Other; Huang, HY (Author) Other; Li, QH (Author) Other; Li, JJ (Author) Other; Noble, WS (Author) Other; Bilmes, JA (Author) Other; Buske, OJ (Author) Other; Hoffman, MM (Author) Other; Sahu, AD (Author) Other; Kharchenko, PV (Author) Other; Park, PJ (Author) Other; Baker, D (Author) Other; Taylor, J (Author) Other; Weng, ZP (Author) Other; Iyer, S (Author) Other; Dong, XJ (Author) Other; Greven, M (Author) Other; Lin, XY (Author) Other; Wang, J (Author) Other; Xi, HLS (Author) Other; Zhuang, JL (Author) Other; Gerstein, M (Author) Other; Alexander, RP (Author) Other; Balasubramanian, S (Author) Other; Cheng, C (Author) Other; Harmanci, A (Author) Other

Journal

Title: Nature

Vol. 489

Pages: 57-74

ISSN: 0028-0836

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 12067 Citations

Scopus - 12689 Citations

Scientific classification

CORDIS: Natural sciences > Biological sciences > Biology > Human biology ; Natural sciences > Biological sciences > Biology > Molecular biology ; Natural sciences > Biological sciences > Biology > Computational biology

FOS: Natural sciences > Biological sciences ; Natural sciences > Computer and information sciences

Other information

Authenticus ID: P-008-5Z1

DOI: 10.1038/nature11247

Abstract (EN): The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) project has systematically mapped regions of transcription, transcription factor association, chromatin structure and histone modification. These data enabled us to assign biochemical functions for 80% of the genome, in particular outside of the well-studied protein-coding regions. Many discovered candidate regulatory elements are physically associated with one another and with expressed genes, providing new insights into the mechanisms of gene regulation. The newly identified elements also show a statistical correspondence to sequence variants linked to human disease, and can thereby guide interpretation of this variation. Overall, the project provides new insights into the organization and regulation of our genes and genome, and is an expansive resource of functional annotations for biomedical research.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 18