Chiral Separations in Preparative Scale: A Medicinal Chemistry Point of View

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Pinto, MMM (Author) Other; Fernandes, C (Author) Other; Tiritan M.E. (Author) FFUP; Carla Fernandes (Author) FFUP

Journal

Title: Molecules

Vol. 25

Final page: 1931

ISSN: 1420-3049

Publisher: MDPI

Indexing

ISI Web of Knowledge - 51 Citations

Scopus - 55 Citations

Other information

Authenticus ID: P-00S-1RT

DOI: 10.3390/molecules25081931

Abstract (EN): Enantiomeric separation is a key step in the development of a new chiral drug. Preparative liquid chromatography (LC) continues to be the technique of choice either during the drug discovery process, to achieve a few milligrams, or to a scale-up during the clinical trial, needing kilograms of material. However, in the last few years, instrumental and technical developments allowed an exponential increase of preparative enantioseparation using other techniques. Besides LC, supercritical fluid chromatography (SFC) and counter-current chromatography (CCC) have aroused interest for preparative chiral separation. This overview will highlight the importance to scale-up chiral separations in Medicinal Chemistry, especially in the early stages of the pipeline of drugs discovery and development. Few examples within different methodologies will be selected, emphasizing the trends in chiral preparative separation. The advantages and drawbacks will be critically discussed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 16