Analysis of chiral drugs in environmental matrices: Current knowledge and trends in environmental, biodegradation and forensic fields

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Ana Rita L. Ribeiro (Author) FEUP; Alexandra S. Maia (Author) Other; Cláudia Ribeiro (Author) Other; Maria Elizabeth Tiritan (Author) FFUP

Journal

Title: TrAC - Trends in Analytical Chemistry

Vol. 124

Pages: 1-12

ISSN: 0165-9936

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 35 Citations

Scopus - 38 Citations

Associated Projects

SAMPREP - Novas técnicas miniaturizadas de preparação de amostra para determinação de micropoluentes em matrizes ambientais

Other information

Authenticus ID: P-00R-HZ4

DOI: 10.1016/j.trac.2019.115783

Abstract (EN): The challenge to develop enantioselective analytical methods to quantify residues of chiral drugs (CDs) in environmental matrices is an actual and imperative issue. It is well known that enantiomers may differ in their biological activities; nevertheless, most environmental analytical methods still ignore the stereochemistry and the discrimination of the enantiomers. The knowledge about their occurrence and ecological impact in biota is crucial for an accurate risk assessment. This critical review highlights the importance of analyzing CDs in environmental matrices for various applications, emphasizing methodological trends. Chromatographic methodologies are the most used and include liquid (LC), gas (GC), supercritical fluid (SFC) and capillary electrophoresis. LC is still the most widely used though trends for greener approaches and the development of GC and SFC methods are also future directions. Some of the most recent applications, namely for environmental monitoring of surface and wastewater, biodegradation studies and forensic analysis, are presented and critically discussed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12