A COMPARISON OF THE LYOAVAILABILITY OF THE ACTIVE INGREDIENT IN TABLETS OBTAINED WITH CLASSIC GRAINS AND WITH EXTRUDED SPHERONIZED GRAINS

• Type: Article in International Scientific Journal
• Date: 1994

Authors

DURU, C (Author) Other; GAUDY, D (Author) Other; Sousa Lobo JM (Author) FFUP; BATAILLE, B (Author) Other; JACOB, M (Author) Other; PUECH, A (Author) Other

Journal

Title: S.T.P. Pharma Sciences

Vol. 4

Pages: 226-229

ISSN: 1157-1489

Publisher: Editions de Sante

Indexing

ISI Web of Knowledge - 1 Citation

Other information

Authenticus ID: P-001-K55

Abstract (EN): Tablets obtained from grains prepared with an oscillating granulator and by axial extrusion followed by spheronization are compared Extrusion/spheronization leads to an improvement in the rheological properties, and also in other properties, such as bulk density and porosity, that indicate the involvement of forces at the upper punch higher than those seen with classic grains to obtain the same tablet hardness. The result is a sustained-release form with the extruded/spheronized grains, the transport mode being of the non-Fickian type.

Language: French

Type (Professor's evaluation): Scientific

No. of pages: 4