Go to:
Logótipo
Comuta visibilidade da coluna esquerda
Você está em: Start > Publications > View > Identification of a biomarker panel for improvement of prostate cancer diagnosis by volatile metabolic profiling of urine
Publication

Publications

Identification of a biomarker panel for improvement of prostate cancer diagnosis by volatile metabolic profiling of urine

Title
Identification of a biomarker panel for improvement of prostate cancer diagnosis by volatile metabolic profiling of urine
Type
Article in International Scientific Journal
Year
2019
Authors
Lima, AR
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Pinto, J
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Azevedo, AI
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Barros Silva, D
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Maria de Lourdes Bastos
(Author)
FFUP
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications View Authenticus page View ORCID page
Carvalho, M
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Journal
Vol. 121
Pages: 857-868
ISSN: 0007-0920
Publisher: Springer Nature
Other information
Authenticus ID: P-00R-88W
Abstract (EN): BACKGROUND: The lack of sensitive and specific biomarkers for the early detection of prostate cancer (PCa) is a major hurdle to improve patient management. METHODS: A metabolomics approach based on GC-MS was used to investigate the performance of volatile organic compounds (VOCs) in general and, more specifically, volatile carbonyl compounds (VCCs) present in urine as potential markers for PCa detection. RESULTS: Results showed that PCa patients (n = 40) can be differentiated from cancer-free subjects (n = 42) based on their urinary volatile profile in both VOCs and VCCs models, unveiling significant differences in the levels of several metabolites. The models constructed were further validated using an external validation set (n = 18 PCa and n = 18 controls) to evaluate sensitivity, specificity and accuracy of the urinary volatile profile to discriminate PCa from controls. The VOCs model disclosed 78% sensitivity, 94% specificity and 86% accuracy, whereas the VCCs model achieved the same sensitivity, a specificity of 100% and an accuracy of 89%. Our findings unveil a panel of 6 volatile compounds significantly altered in PCa patients' urine samples that was able to identify PCa, with a sensitivity of 89%, specificity of 83%, and accuracy of 86%. CONCLUSIONS: It is disclosed a biomarker panel with potential to be used as a non-invasive diagnostic tool for PCa.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 12
Documents
We could not find any documents associated to the publication.
Related Publications

Of the same journal

Tenascin and oncofetal fibronectin - Oncofetal markers or indicators of extracellular matrix remodelling? (1996)
Another Publication in an International Scientific Journal
David L; Sobrinho Simoes, M; Ikeda, Y
P53 MUTATIONS IN GASTRIC CARCINOMAS (1992)
Another Publication in an International Scientific Journal
Seruca, R; David L; HOLM, R; NESLAND, JM; FANGAN, BM; CASTEDO, S; Sobrinho Simoes, M; BORRESEN, AL
Prognostic factors in gastric carcinoma (1997)
Another Publication in an International Scientific Journal
Carneiro F; Ribeiro, MM; Sobrinho Simoes, M; Setala, L; Kosma, VM; Eskelinen, M; Syrjanen, K; Alhava, E
HIV and HPV infections and ocular surface squamous neoplasia: systematic review and meta-analysis (2013)
Another Publication in an International Scientific Journal
Carreira, H; Coutinho, F; Carrilho, C; Lunet N
UNUSUAL GROWTH-CHARACTERISTICS OF HUMAN-MELANOMA XENOGRAFTS IN THE NUDE-MOUSE - A MODEL FOR DESMOPLASIA, DORMANCY AND PROGRESSION (1992)
Article in International Scientific Journal
Fátima Gärtner; FEARNS, C; WILSON, EL; CAMPBELL, JAH; DOWDLE, EB

See all (30)

Recommend this page Top
Copyright 1996-2025 © Faculdade de Direito da Universidade do Porto  I Terms and Conditions  I Acessibility  I Index A-Z
Page created on: 2025-07-10 at 04:08:59 | Privacy Policy | Personal Data Protection Policy | Whistleblowing