Comprehensive review of cardiovascular toxicity of drugs and related agents

• Type: Another Publication in an International Scientific Journal
• Date: 2018

Authors

Mladenka, P (Author) Other; Applova, L (Author) Other; Patocka, J (Author) Other; Costa, VM (Author) Other; Fernando Remiao (Author) FFUP; Pourova, J (Author) Other; Mladenka, A (Author) Other; Karlickova, J (Author) Other; Jahodar, L (Author) Other; Voprsalova, M (Author) Other; Varner, KJ (Author) Other; Sterba, M (Author) Other

Journal

Title: Medicinal Research Reviews

Vol. 38

Pages: 1332-1403

ISSN: 0198-6325

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 60 Citations

Other information

Authenticus ID: P-00R-A7W

DOI: 10.1002/med.21476

Abstract (EN): Cardiovascular diseases are a leading cause of morbidity and mortality in most developed countries of the world. Pharmaceuticals, illicit drugs, and toxins can significantly contribute to the overall cardiovascular burden and thus deserve attention. The present article is a systematic overview of drugs that may induce distinct cardiovascular toxicity. The compounds are classified into agents that have significant effects on the heart, blood vessels, or both. The mechanism(s) of toxic action are discussed and treatment modalities are briefly mentioned in relevant cases. Due to the large number of clinically relevant compounds discussed, this article could be of interest to a broad audience including pharmacologists and toxicologists, pharmacists, physicians, and medicinal chemists. Particular emphasis is given to clinically relevant topics including the cardiovascular toxicity of illicit sympathomimetic drugs (e.g., cocaine, amphetamines, cathinones), drugs that prolong the QT interval, antidysrhythmic drugs, digoxin and other cardioactive steroids, beta-blockers, calcium channel blockers, female hormones, nonsteroidal anti-inflammatory, and anticancer compounds encompassing anthracyclines and novel targeted therapy interfering with the HER2 or the vascular endothelial growth factor pathway.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 72