Characterization of the pJB12 Plasmid from Pseudomonas aeruginosa Reveals Tn6352, a Novel Putative Transposon Associated with Mobilization of the bla(VIM-2)-Harboring In58 Integron

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Botelho, J (Author) Other; Grosso, F (Author) Other; Luisa Peixe (Author) FFUP

Journal

Title: Antimicrobial Agents and Chemotherapy

Vol. 61

ISSN: 0066-4804

Publisher: American Society for Microbiology

Indexing

ISI Web of Knowledge - 12 Citations

Scopus - 15 Citations

Other information

Authenticus ID: P-00M-QVT

DOI: 10.1128/aac.02532-16

Abstract (EN): The bla(VIM-2)-carrying In58 integron has been linked to a chromosomal location in different bacterial species, including Pseudomonas aeruginosa. This work reports the first fully sequenced In58-harboring plasmid, which is significantly different from the two previously identified bla(VIM-2)-carrying plasmids in P. aeruginosa. bla(VIM-2) might have been acquired by transposition of Tn6352, a novel transposon composed of the In58 and ISPa17 elements. The recognition of similar inverted repeat (IR) sites by ISPa17 reveals a common mobilization process associated with acquisition of the bla(VIM-2) and bla(VIM-1) genes.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6