Multicenter Study of Cronobacter sakazakii Infections in Humans, Europe, 2017

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Lepuschitz, S (Author) Other; Ruppitsch, W (Author) Other; Pekard Amenitsch, S (Author) Other; Forsythe, SJ (Author) Other; Cormican, M (Author) Other; Mach, RL (Author) Other; Pierard, D (Author) Other; Allerberger, F (Author) Other; Allerberger, F (Author) Other; Andrasevic, AT (Author) Other; Balode, A (Author) Other; Barbut, F (Author) Other; Codita, I (Author) Other; Connican, M (Author) Other; Ferguson, C (Author) Other; Heczko, P (Author) Other; Holy, O (Author) Other; Kantardjiev, T (Author) Other; Kuijper, EJ (Author) Other; Leegaard, TM (Author) Other; Luisa Peixe (Author) FFUP; Pierard, D (Author) Other; Rautelin, H (Author) Other; Rupnik, M (Author) Other; Schonning, K (Author) Other; Stephan, R (Author) Other; Toniolo, A (Author) Other; Tosic, T (Author) Other; Valdezate, S (Author) Other; von Mueller, L (Author) Other; Zerva, L (Author) Other; Zinieri Panayide, B (Author) Other

Journal

Title: Emerging Infectious Diseases

Vol. 25

Pages: 515-522

ISSN: 1080-6040

Publisher: Centers for Disease Control and Prevention (CDC)

Indexing

ISI Web of Knowledge - 0 Citations

Other information

Authenticus ID: P-00Q-8X0

DOI: 10.3201/eid2503.181652

Abstract (EN): Cronobacter sakazakii has been documented as a cause of life-threating infections, predominantly in neonates. We conducted a multicenter study to assess the occurrence of C. sakazakii across Europe and the extent of clonality for outbreak detection. National coordinators representing 24 countries in Europe were requested to submit all human C. sakazakii isolates collected during 2017 to a study center in Austria. Testing at the center included species identification by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, subtyping by whole-genome sequencing (WGS), and determination of antimicrobial resistance. Eleven countries sent 77 isolates, including 36 isolates from 2017 and 41 historical isolates. Fifty-nine isolates were confirmed as C. sakazakii by WGS, highlighting the challenge of correctly identifying Cronobacter spp. WGS-based typing revealed high strain diversity, indicating absence of multi-national outbreaks in 2017, but identified 4 previously unpublished historical outbreaks. WGS is the recommended method for accurate identification, typing, and detection of this pathogen.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8