The evolutionary road to invertebrate thyroid hormone signaling: Perspectives for endocrine disruption processes

• Type: Another Publication in an International Scientific Journal
• Date: 2019

Authors

Sainath, SB (Author) Other; Andre, A (Author) Other; Filipe F C Castro (Author) FCUP; Santos, MM (Author) FCUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Vol. 223

Pages: 124-138

ISSN: 1532-0456

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-00Q-QEJ

DOI: 10.1016/j.cbpc.2019.05.014

Abstract (EN): Thyroid hormones (THs) are the only iodine-containing hormones that play fundamental roles in chordates and non-chordates. The chemical nature, mode of action and the synthesis of THs are well established in mammals and other vertebrates. Although thyroid-like hormones have been detected in protostomes and non-chordate deuterostomes, TH signaling is poorly understood as compared to vertebrates, particularly in protostomes. Therefore, the central objective of this article is to review TH system components and TH-induced effects in non-vertebrate chordates, non-chordate deuterostomes and protostomes based on available genomes and functional information. To accomplish this task, we integrate here the available knowledge on the THs signaling across non-vertebrate chordates, non-chordate deuterostomes and protostomes by considering studies encompassing TH system components and physiological actions of THs. We also address the possible interactions of thyroid disrupting chemicals and their effects in protostomes and non-chordate deuterostomes. Finally, the perspectives on current and future challenges are discussed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15