The opportunistic effect of exosomes on Non-Hodgkin Lymphoma microenvironment modulation

• Type: Another Publication in an International Scientific Journal
• Date: 2019

Authors

Fernandes, M (Author) Other; Teixeira, AL (Author) Other; Rui Medeiros (Author) ICBAS

Journal

Title: Critical Reviews in Oncology/Hematology

Vol. 144

ISSN: 1040-8428

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-00R-BWF

DOI: 10.1016/j.critrevonc.2019.102825

Abstract (EN): There has been a shift in the paradigm of Non-Hodgkin lymphomas, changing from the classical genetic aberration-based model to a more complex and dynamic model involving tumor microenvironment interactions. In this instance, exosomes have emerged as important mediators in intercellular communication by providing survival and proliferation signals, licensing immune evasion and acquisition of drug resistance. The capability to transfer molecular cargo made exosomes a focus of research to understand cancer pathogenesis and its progression pathways. Several studies identified exosomes transporting tumor-released components in peripheral blood and focused on understanding their clinical relevance in the diagnosis, prognostic and in monitoring cancer progression. Moreover, due to their biophysical properties and physiological function, exosomes have drawn attention as potential therapeutic target and drug delivery vehicles. This review will discuss the function of exosomes in Non-Hodgkin lymphomagenesis, highlight their potential as diagnosis and prognosis biomarkers, and as new therapeutic opportunities in lymphoma management.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12