Estrogen receptors genotypes and canine mammary neoplasia

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Canadas Sousa, A (Author) Other; Santos, M (Author) Other; Leal, B (Author) Other; Rui Medeiros (Author) ICBAS; Dias Pereira, P (Author) Other

Journal

Title: BMC Veterinary Research

Vol. 15

ISSN: 1746-6148

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 12 Citations

Scopus - 17 Citations

Other information

Authenticus ID: P-00R-24X

DOI: 10.1186/s12917-019-2062-y

Abstract (EN): Background Estrogens are essential for the development and proper function of several hormone-dependent organs. There are, however, several lines of evidence associating estrogens with mammary carcinogenesis. A marked individual genetic variability concerning estrogens biosynthesis, metabolism and mechanism of action was recognized and associated with human breast cancer susceptibility, clinical features and progression. Although some genetic variations in canine ESR1 gene were reported, their influence in clinicopathological features and progression of canine mammary tumors has not been fully evaluated. This study aims to assess the influence of SNPs in ESR1 gene (rs397512133, rs397510462, rs851327560, rs397510612, rs852887655, rs852684753 and rs852398698) in canine mammary tumors characteristics and progression. A group of 155 non-neutered bitches with mammary tumors was included in the study. Follow-up information was assessed 24 months after surgery. Results Genetic profiles associated with a later onset of mammary tumors and less aggressive clinicopathological features, namely smaller tumor size (<= 3 cm) with extensive tubular differentiation and low canine-adapted prognostic index (vet-NPI), were identified in this study. Conclusions Our data suggest that the ESR1 genetic profile may help on the decision regarding the selection of individual tailored preventive measures against canine mammary tumors development, such as early neutering.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10