Epistatic Interaction of CYP1A1 and COMT Polymorphisms in Cervical Cancer

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Matos, A (Author) Other; Castelao, C (Author) Other; da Silva, AP (Author) Other; Alho, I (Author) Other; Bicho, M (Author) Other; Rui Medeiros (Author) ICBAS; Bicho, MC (Author) Other

Journal

Title: Oxidative Medicine and Cellular Longevity

Vol. 2016

Pages: 1-7

ISSN: 1942-0900

Publisher: Hindawi

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 12 Citations

Other information

Authenticus ID: P-00K-3RA

DOI: 10.1155/2016/2769804

Abstract (EN): There is a clear association between the excessive and cumulative exposure to estrogens and the development of cancer in hormone-sensitive tissues, such as the cervix. We studied the association of CYP1A1 M1 (rs4646903) and COMT (rs4680) polymorphisms in 130 cervical cancer cases (c-cancer) and 179 controls. The CYP1A1 TT genotype was associated with a lower risk for c-cancer (OR = 0.39, p = 0.002). The allele C of CYP1A1 was a risk for c-cancer (OR = 2.29, p = 0.002). Women with COMT LL genotype had a higher risk of developing c-cancer (OR = 4.83, p < 0.001). For the interaction of the CYP1A1&COMT, we observed that TC&HL genotypes had a greater risk for c-cancer (OR = 6.07, p = 0.006) and TT&HL genotypes had a protection effect (OR = 0.24, p < 0.001). The CYP1A1 TT and COMT LL genotypes had higher estradiol levels in c-cancer (p < 0.001 and p = 0.037, resp.). C-cancer is associated with less production of 2-methoxy-estradiol resultant of functional polymorphisms of CYP1A1 and COMT, separately. CYP1A1 and COMT work in a metabolic sequence and their interaction could lead to an alternative pathway of estrogen metabolism with production of 16-OH-estrone that is more proliferative.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7