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EGCG intestinal absorption and oral bioavailability enhancement using folic acid-functionalized nanostructured lipid carriers

Title
EGCG intestinal absorption and oral bioavailability enhancement using folic acid-functionalized nanostructured lipid carriers
Type
Article in International Scientific Journal
Year
2019
Authors
Granja, A
(Author)
Other
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Neves, AR
(Author)
Other
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Pinheiro, M
(Author)
Other
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Salette Reis
(Author)
FFUP
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Journal
Title: HeliyonImported from Authenticus Search for Journal Publications
Vol. 5
ISSN: 2405-8440
Publisher: Elsevier
Other information
Authenticus ID: P-00Q-S42
Abstract (EN): This work aimed to develop folic acid-functionalized nanostructured lipid carriers (NLC) loading epigallocatechin-3- gallate (EGCG) to increase its oral bioavailability. An active targeting strategy was used and these nanoparticles (NPs) were fully characterized. The NP's effect on Caco-2 cell viability was evaluated and the apparent permeability (P-app) on a Caco-2 cell monolayer was determined. The results demonstrated that the developed NPs exhibited adequate physicochemical characteristics for oral administration and were found to be biocompatible with epithelial Caco-2 cells. Further, folic acid-functionalized EGCG-loaded NLC significantly increased EGCG transport across the intestinal barrier, promoting a 1.8- fold increase in its apparent permeability (P-app). Taken together, these results support that the developed NLC can be used as a promising carrier for safer and efficient management of several diseases since the pharmacokinetic (PK) properties of EGCG were improved with this nanomedicine-based strategy.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 6
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