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Hyaluronic acid-conjugated pH-sensitive liposomes for targeted delivery of prednisolone on rheumatoid arthritis therapy

Title
Hyaluronic acid-conjugated pH-sensitive liposomes for targeted delivery of prednisolone on rheumatoid arthritis therapy
Type
Article in International Scientific Journal
Year
2018
Authors
Gouveia, VM
(Author)
Other
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Lopes de Araujo, J
(Author)
Other
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Costa Lima, SAC
(Author)
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Nunes, C
(Author)
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Salette Reis
(Author)
FFUP
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Journal
Title: NanomedicineImported from Authenticus Search for Journal Publications
Vol. 13
Pages: 1037-1049
ISSN: 1743-5889
Other information
Authenticus ID: P-00Q-E80
Abstract (EN): Aim: The treatment of rheumatoid arthritis remains a challenge as available therapies still entail the risk of deleterious off-target effects. The present study describes hyaluronic acid-conjugated pH-sensitive liposomes as an effective drug delivery-targeting strategy to synovial cells. Materials & methods: Therapeutic, cytotoxic and targeting potential of developed liposomes were studied in vitro using macrophages and fibroblasts cell lines. Results & Conclusion: Results suggest an enhanced cellular uptake of conjugated liposomes, mainly mediated by caveolae- and clathrin-dependent endocytosis. In vitro release studies demonstrated that prednisolone was preferentially released under acidic conditions mimicking intracellular endosomal compartments. Overall, results revealed that conjugated pH-sensitive liposomes are a promising nanoapproach for the targeted delivery of prednisolone within inflamed synovial cells for rheumatoid arthritis treatment.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 13
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