Hyaluronic acid-conjugated pH-sensitive liposomes for targeted delivery of prednisolone on rheumatoid arthritis therapy

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Gouveia, VM (Author) Other; Lopes de Araujo, J (Author) Other; Costa Lima, SAC (Author) Other; Nunes, C (Author) Other; Salette Reis (Author) FFUP

Journal

Title: Nanomedicine

Vol. 13

Pages: 1037-1049

ISSN: 1743-5889

Publisher: Future Medicine Ltd.

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 19 Citations

Other information

Authenticus ID: P-00Q-E80

DOI: 10.2217/nnm-2017-0377

Abstract (EN): Aim: The treatment of rheumatoid arthritis remains a challenge as available therapies still entail the risk of deleterious off-target effects. The present study describes hyaluronic acid-conjugated pH-sensitive liposomes as an effective drug delivery-targeting strategy to synovial cells. Materials & methods: Therapeutic, cytotoxic and targeting potential of developed liposomes were studied in vitro using macrophages and fibroblasts cell lines. Results & Conclusion: Results suggest an enhanced cellular uptake of conjugated liposomes, mainly mediated by caveolae- and clathrin-dependent endocytosis. In vitro release studies demonstrated that prednisolone was preferentially released under acidic conditions mimicking intracellular endosomal compartments. Overall, results revealed that conjugated pH-sensitive liposomes are a promising nanoapproach for the targeted delivery of prednisolone within inflamed synovial cells for rheumatoid arthritis treatment.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13