Drug-related morbidity and mortality in Brazil: A systematic review of observational studies [Morbidade e mortalidade relacionadas a medicamentos no Brasil: Revisão sistemática de estudos observacionais]

• Type: Article in International Scientific Journal
• Date: 2014

Authors

de Souza, TT (Author) Other; Godoy, RR (Author) Other; Rotta, I (Author) Other; Pontarolo, R (Author) Other; Fernandez Llimos, F (Author) Other; Correr, CJ (Author) Other

Journal

Title: Revista de Ciencias Farmaceuticas Basica e Aplicada

Vol. 35

Pages: 519-532

ISSN: 1808-4532

Publisher: Universidade Estadual Paulista - UNESP

Indexing

Scopus - 15 Citations

Other information

Authenticus ID: P-00G-G4C

Abstract (EN): This study evaluated the drug-related morbidity and mortality in Brazil, its prevalence, the pharmacological groups and risk factors associated. We performed a systematic review of observational studies published up to August 2012, without restriction start date, in the databases Medline, Lilacs, SciELO, EMBASE, IPA, Science Direct, Scopus and Web of Science. Were selected national studies evaluating the occurrence of any damage caused by medications. We included 45 studies. The highest prevalence of adverse drug events was observed in hospitals for adults and elderly, ranging from 15.6% to 34.1%. In nurseries, 19.9% of the children suffered some adverse drug reaction. In emergency departments, 25% of adults and elderly suffered harm related to therapeutic failure. Medications acting on the central nervous system were the main pharmacological group involved. The main risk factors were age, comorbidities and use of more than 5 medications. The results are alarming and demonstrate the need for screening and medication risk stratification in the population, and preventive or early interventions that can reduce the impact of drug-related morbidity and mortality in Brazil.

Language: Portuguese

Type (Professor's evaluation): Scientific