Adverse events and treatment failure leading to discontinuation of recently approved antipsychotic drugs in schizophrenia: A network meta-analysis

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Tonin, FS (Author) Other; Piazza, T (Author) Other; Wiens, A (Author) Other; Fernandez Llimos, F (Author) Other; Pontarolo, R (Author) Other

Journal

Title: Schizophrenia Research

Vol. 169

Pages: 483-485

ISSN: 0920-9964

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 3 Citations

Other information

Authenticus ID: P-00J-YYN

DOI: 10.1016/j.schres.2015.09.019

Abstract (EN): Objective: We aimed to gather evidence of the discontinuation rates owing to adverse events or treatment failure for four recently approved antipsychotics (asenapine, blonanserin, iloperidone, and lurasidone). Methods: A systematic review followed by pairwise meta-analysis and mixed treatment comparison meta-analysis (MTC) was performed, including randomized controlled trials (RCTs) that compared the use of the above-mentioned drugs versus placebo in patients with schizophrenia. An electronic search was conducted in PubMed, Scopus, Science Direct, Scielo, the Cochrane Library, and International Pharmaceutical Abstracts (January 2015). The included trials were at least single blinded. The main outcome measures extracted were discontinuation owing to adverse events and discontinuation owing to treatment failure. Results: Fifteen RCTs were identified (n = 5400 participants) and 13 of them were amenable for use in our meta-analyses. No significant differences were observed between any of the four drugs and placebo as regards discontinuation owing to adverse events, whether in pairwise meta-analysis or in MTC. All drugs presented a better profile than placebo on discontinuation owing to treatment failure, both in pairwise meta-analysis and MTC. Asenapinewas found to be the best therapy in terms of tolerability owing to failure, while lurasidone was the worst treatment in terms of adverse events. The evidence around blonanserin is weak. Conclusion: MTCs allowed the creation of two different rank orders of these four antipsychotic drugs in two outcome measures. This evidence-generating method allows direct and indirect comparisons, supporting approval and pricing decisions when lacking sufficient, direct, head-to-head trials. (C) 2015 Published by Elsevier B.V.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3