Study of the effect of thiourea and N-ethyl groups on antibacterial activity of rhodamine-labeled 3,4-HPO iron chelators against Gram ( plus /-) bacteria

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Moniz, T (Author) Other; Feio, M (Author) Other; Silva, D (Author) Other; de Castro, B (Author) Other; Maria Rangel (Author) ICBAS

Journal

Title: Medicinal Chemistry Research

Vol. 27

Pages: 1472-1477

ISSN: 1054-2523

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 4 Citations

Other information

Authenticus ID: P-00N-QZF

DOI: 10.1007/s00044-018-2165-1

Abstract (EN): In the sequence of the work in which we identified functional groups of rhodamine labeled 3,4-HPO chelators that are crucial for their activity against Mycobacterium avium infection we now scrutinize if the same groups are also relevant for the chelators antibacterial activity against Gram (+/-) bacteria. In this new infection scenario, we confirmed that a thiourea linkage and N-ethyl substituents on the xanthene ring are important and there is an advantage of the association of both groups in the molecular framework. In particular, we found that three hexadentate chelators (MRH7, MRH8, and MRH10) inhibit bacterial growth of Staphylococcus (S). aureus ATCC 25923 and S. epidermis ATCC 12228 and one hexadentate chelator (MRH7) also inhibits the growth of Escherichia (E.) coli ATCC 25922.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6