EFFECTS OF FORSKOLIN, DIBUTYRYL-CYCLIC-AMP, AND 5'-N-ETHYLCARBOXAMIDE ADENOSINE ON NA-22 UPTAKE BY RAT-BRAIN SYNAPTOSOMES STIMULATED BY VERATRIDINE

• Type: Article in International Scientific Journal
• Date: 1992

Authors

LOBO, MGB (Author) ICBAS; RIBEIRO, JA (Author) Other

Journal

Title: Journal of Neurochemistry

Vol. 58

Pages: 1033-1037

ISSN: 0022-3042

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-001-PSZ

DOI: 10.1111/j.1471-4159.1992.tb09358.x

Abstract (EN): The effects of forskolin, dibutyryl cyclic AMP, and 5'-N-ethylcarboxamide adenosine on specific Na-22 uptake by synaptosomes stimulated by veratridine were investigated. All substances inhibited Na-22 uptake, with forskolin more potent than 5'-N-ethylcarboxamide and this latter one more potent than dibutyryl cyclic AMP. In the absence of preincubation with forskolin, this substance caused little or no effect on Na-22 uptake by synaptosomes. In the presence of the adenosine antagonist dipropylsulfophenylxanthine, the inhibitory effect of 5'-N-ethylcarboxamide adenosine on Na-22 uptake was consistently antagonized. The results were interpreted as forskolin and 5'-N-ethylcarboxamide adenosine increasing cyclic AMP accumulation, and dibutyryl cyclic AMP mimicking it, and by these mechanisms decreasing sodium uptake through the sodium channels.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5