BRCA1/P53: Two strengths in cancer chemoprevention

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Raimundo, L (Author) Other; Ramos, H (Author) Other; Loureiro, JB (Author) Other; Calheiros, J (Author) Other; Lucilia Saraiva (Author) FFUP

Journal

Title: Biochimica et Biophysica Acta - Reviews on Cancer

Vol. 1873

ISSN: 0304-419X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 8 Citations

Other information

Authenticus ID: P-00R-MCK

DOI: 10.1016/j.bbcan.2020.188339

Abstract (EN): Increasing emphasis has been given to prevention as a feasible approach to reduce the cancer burden. However, for its clinical success, further advances are required to identify effective chemopreventive agents. This review affords a critical and up-to-date discussion of issues related to cancer prevention, including an in-depth knowledge on BRCA1 and p53 tumor suppressor proteins as key molecular players. Indeed, it compiles the most recent advances on the topic, highlighting the unique potential of BRCA1 and p53 germline mutations as molecular biomarkers for risk assessment and targets for chemoprevention. Relevant evidences are herein provided supporting the effectiveness of distinct pharmacological agents in cancer prevention, by targeting BRCA1 and p53. Moreover, the rationale for using germline mutant BRCA1- or p53-related cancer syndromes as model systems to investigate effective chemopreventive agents is also addressed. Altogether, this work provides an innovative conception about the dependence on p53 and BRCA1 co-inactivation in tumor formation and development, emphasizing the relationship between these two proteins as an encouraging direction for future personalized pharmacological interventions in cancer prevention.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 16