Automated and objective measures of gait dynamics in camptocormia Parkinson's Disease subthalamic deep brain stimulation

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Carolina Soares (Author) Other; Maria do Carmo Vilas Boas (Author) Other; Elodie Murias Lopes (Author) Other; Hugo Choupina (Author) Other; Ricardo Soares dos Reis (Author) Other; Diogo Fitas (Author) Other; João Paulo Silva Cunha (Author) FEUP; Pedro Monteiro (Author) Other; Paulo Linhares (Author) Other; Maria José Rosas (Author) Other

Journal

Title: Clinical Neurology and Neurosurgery

Vol. 186

Pages: 1-5

ISSN: 0303-8467

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 1 Citation

Other information

Authenticus ID: P-00Q-W14

DOI: 10.1016/j.clineuro.2019.105537

Abstract (EN): Objective: Axial motor features are common in Parkinson's disease (PD). These include gait impairment and postural abnormalities, such as camptocormia. The response of these symptoms to deep brain stimulation (DBS) is variable and difficult to assess objectively. For the first time, this study analyzes the treatment outcomes of two PD patients with camptocormia that underwent bilateral subthalamic nucleus (STN)-DBS evaluated with disruptive technologies. Patients and methods: Two patients with PD and camptocormia who underwent STN-DBS were included. Gait parameters were quantitatively assessed before and after surgery by using the NeuroKinect system and the camptocormia angle was measured using the camptoapp. Results: After surgery, patient 1 improved 29 points in the UPDRS-III. His camptocormia angle was 68 degrees before and 38 degrees after surgery. Arm and knee angular amplitudes (117.32 +/- 7.47 vs 134.77 +/- 2.70; 144.51 +/- 7.47 vs 169.08 +/- 3.27) and arm swing (3.59 +/- 2.66 vs 5.40 +/- 1.76 cm) improved when compared with his pre-operative measurements. Patient 2 improved 22 points in the UPDRS-III after surgery. Her camptocormia mostly resolved (47 degrees before to 9 degrees after surgery). Gait analysis revealed improvement of stride length (0.29 +/- 0.03 vs 0.35 +/- 0.03 m), stride width (18.25 +/- 1.16 vs 17.9 +/- 0.84 cm), step velocity (0.91 +/- 0.57 vs 1.33 +/- 0.48 m/s), arm swing (4.51 +/- 1.01 vs 7.38 +/- 2.71 cm) and arm and hip angular amplitudes (131.57 +/- 2.45 degrees vs 137.75 +/- 3.18; 100.51 +/- 1.56 vs 102.18 +/- 1.77 degrees) compared with her preoperative results. Conclusion: The gait parameters and camptocormia of both patients objectively improved after surgery, as assessed by the two quantitative measurement systems. STN-DBS might have a beneficial effect on controlling axial posturing and gait, being a potential surgical treatment for camptocormia in patients with PD. However, further studies are needed to derive adequate selection criteria for this patient population.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5