Connectivity patterns of pallidal DBS electrodes in focal dystonia: A diffusion tensor tractography study

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Rozanski, VE (Author) Other; Vollmar, C (Author) Other; Cunha, JPS (Author) FEUP; Neves Tafula, SMN (Author) FEUP; Ahmadi, SA (Author) Other; Patzig, M (Author) Other; Mehrkens, JH (Author) Other; Boetzel, K (Author) Other

Journal

Title: NeuroImage

Vol. 84

Pages: 435-442

ISSN: 1053-8119

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 25 Citations

Scopus - 29 Citations

Other information

Authenticus ID: P-008-EPK

DOI: 10.1016/j.neuroimage.2013.09.009

Abstract (EN): Deep brain stimulation (DBS) of the internal pallidal segment (GPi: globus pallidus internus) is gold standard treatment for medically intractable dystonia, but detailed knowledge of mechanisms of action is still not available. There is evidence that stimulation of ventral and dorsal GPi produces opposite motor effects. The aim of this study was to analyse connectivity profiles of ventral and dorsal GPi. Probabilistic tractography was initiated from DBS electrode contacts in 8 patients with focal dystonia and connectivity patterns compared. We found a considerable difference in anterior-posterior distribution of fibres along the mesial cortical sensorimotor areas between the ventral and dorsal GPi connectivity. This finding of distinct GPi connectivity profiles further confirms the clinical evidence that the ventral and dorsal GPi belong to different functional and anatomic motor subsystems. Their involvement could play an important role in promoting clinical DBS effects in dystonia.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8