Evaluation of the neuroprotective and antidiabetic potential of phenol-rich extracts from virgin olive oils by in vitro assays

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Figueiredo Gonzalez, M (Author) Other; Reboredo Rodriguez, P (Author) Other; Gonzalez Barreiro, C (Author) Other; Simal Gandara, J (Author) Other; Patricia Valentao (Author) FFUP; Carrasco Pancorbo, A (Author) Other; Paula B Andrade (Author) FFUP; Cancho Grande, B (Author) Other

Journal

Title: Food Research International

Vol. 106

Pages: 558-567

ISSN: 0963-9969

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 21 Citations

Other information

Authenticus ID: P-00N-K77

DOI: 10.1016/j.foodres.2018.01.026

Abstract (EN): In this work, phenol-rich extracts from 'Cornicabra' and 'Picual' virgin-olive oils (EVOOs) were examined, for the first time, to establish their capacity to inhibit key enzymes involved in Alzheimer's disease (AD) (acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and 5-lipoxygenase (LOX)), major depressive disorder (MDD) and Parkinson's disease (PD) (monoamine oxidases: hMAO-A and hMAO-B respectively), and diabetes mellitus (DM) (alpha-glucosidase and alpha-amylase). 'Cornicabra' displayed the best inhibitory activity against all enzymes, when compared to 'Picual': BuChE (IC50 = 156 +/- 4 and 308 +/- 33 mg mL(-1)), LOX (IC50 = 26 +/- 0.5 and 37 +/- 3 mg mL(-1)), hMAO-A (IC50 = 20 +/- 2 and 37 +/- 0.2 mg mL-1), hMAO-B (IC50 = 131 +/- 7 and 215 +/- 13 mg mL(-1)) and alpha-glucosidase (IC50 = 154 +/- 17 and 251 +/- 31 mg mL(-1)), respectively. The behaviour observed can be associated with the higher content of secoiridoids, lignans and phenolic acids in 'Cornicabra' EVOO.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10