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Tuning protein folding in lysosomal storage diseases: the chemistry behind pharmacological chaperones

Title
Tuning protein folding in lysosomal storage diseases: the chemistry behind pharmacological chaperones
Type
Article in International Scientific Journal
Year
2018
Authors
David M Pereira
(Author)
FFUP
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Patricia Valentao
(Author)
FFUP
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Paula B Andrade
(Author)
FFUP
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Journal
Title: Chemical ScienceImported from Authenticus Search for Journal Publications
Vol. 9
Pages: 1740-1752
ISSN: 2041-6520
Other information
Authenticus ID: P-00N-MJD
Abstract (EN): Misfolding of proteins is the basis of several proteinopathies. Chemical and pharmacological chaperones are small molecules capable of inducing the correct conformation of proteins, thus being of interest for human therapeutics. The most recent developments in medicinal chemistry and in the drug development of pharmacological chaperones are discussed, with focus on lysosomal storage diseases.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 13
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