Hepcidin and diabetes are independently related with soluble transferrin receptor levels in chronic dialysis patients

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Cristina Catarino (Author) FFUP; Bronze da Rocha, E (Author) FFUP; Rocha Pereira, P (Author) Other; do Sameiro Faria, M (Author) Other; José Oliveira (Author) FMUP; Madureira, J (Author) Other; Fernandes, JC (Author) Other; Miranda, V (Author) Other; Alice Santos Silva (Author) FFUP; Belo, L (Author) FFUP; Rocha, S (Author) Other; Valente, MJ (Author) Other; Coimbra, S (Author) Other

Journal

Title: Renal Failure

Vol. 41

Pages: 662-672

ISSN: 0886-022X

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-00Q-V43

DOI: 10.1080/0886022x.2019.1635893

Abstract (EN): Background: Soluble transferrin receptor (sTfR) is a biomarker of erythropoiesis, which is often impaired in dialysis patients. The aim of our study was to evaluate sTfR levels in chronically dialyzed patients and assess potential determinants of its levels. Methods: We performed a cross-sectional study by evaluating 246 end-stage renal disease patients undergoing dialysis and 32 healthy controls. Circulating levels of interleukin (IL)-6, C-reactive protein (CRP), tumor necrosis factor (TNF)-alpha, hepcidin, sTfR, growth differentiation factor 15 (GDF15), and traditional iron metabolism markers were measured, as well as hemogram parameters. Clinical data was obtained from all patients. Results: Compared to controls, patients presented similar values of sTfR, reticulocytes and reticulocyte production index (RPI), and significantly higher levels of IL-6, CRP, ferritin, hepcidin, TNF-alpha, and GDF15. Iron, transferrin, hemoglobin levels, erythrocyte count, mean cell hemoglobin (MCH), and mean cell hemoglobin concentration (MCHC) values were significantly lower in dialysis group. Within patients, sTfR values were higher in diabetic patients and were positively and significantly correlated with reticulocytes and erythrocytes, RPI, and therapeutic doses of erythropoiesis stimulating agents (ESA) and intravenous iron; and inversely and significantly correlated with circulating iron, ferritin, transferrin saturation, hepcidin, MCH, and MCHC. In multiple linear regression analysis, ESA dose, RPI, serum iron, diabetes, and hepcidin levels were independently associated with sTfR levels in dialysis patients and, thus, with erythropoiesis. Conclusion: Our data suggest that, besides RPI and ESA dose, diabetes and hepcidin are closely related to erythropoiesis in dialysis patients. The influence of diabetes on sTfR levels deserves further investigation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11