Flow characterization of a pharmaceutical excipient using the shear cell method

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Salustio, PJ (Author) Other; Inacio, C (Author) Other; Nunes, T (Author) Other; Paulo Silva (Author) FFUP; Paulo Costa (Author) FFUP

Journal

Title: Pharmaceutical Development and Technology

Vol. 25

Pages: 237-244

ISSN: 1083-7450

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 3 Citations

Other information

Authenticus ID: P-00R-DEM

DOI: 10.1080/10837450.2019.1688348

Abstract (EN): The powders used in the production of solid dosage forms must have ability to flow that allows their industrial processing. Although this property has been studied for most of the powders, in this study non-expected flow behaviors were observed for the model excipient used, Microcrystalline Cellulose (MCC). Several fractions with different sizes were fractioned by sieving of the model excipient and its flow behaviors were analyzed by different methods. The shear cell results showed an increase of the flowability index (ff(c)) with the increase of the particle size and consolidation stress. Some related information has been referenced in the literature, however, in this work it was shown for different size fractions that the ff(c) decreased above a certain consolidation stress value (2000-4000 N/m(2)). The explanation of this phenomenon is based on the increase of cohesion. Furthermore, it was also observed that the fractions with sizes between 125-180 mu m present a ff(c) higher than bulk powder (F-Total) with similar percentile (D(V)50) indicating that this index is dependent on the size of the particles and also on its size distribution range. Thus, it can be affirmed that more homogeneous samples in size and with a narrower distribution present a better ff(c).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8