Burden of disease attributable to exposure to aflatoxins in Portugal using Human biomonitoring data

• Type: Summary of Presentation in an International Conference
• Date: 2019

Authors

Martins, C (Author) Other; Vidal, A (Author) Other; De Boevre, M (Author) Other; De Saeger, S (Author) Other; Nunes, C (Author) Other; Torres, Duarte (Author) FCNAUP; Goios, A (Author) Other; Lopes, C (Author) Other; Alvito, P (Author) Other; Assunção, R (Author) Other

Conference proceedings International

Title: European Journal of Public Health. 2019; Vol.29, n.º 4 (12th European Public Health Conference abstracts)

Pages: 489-489

12th European Public Health Conference: Building bridges for solidarity and public health

Marselha, França, 20 a 23 de novembro de 2019

Indexing

ISI Web of Knowledge - 0 Citations

Scientific classification

FOS: Medical and Health sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-00R-K8P

DOI: 10.1093/eurpub/ckz186.286

Abstract (EN): <jats:title>Abstract</jats:title> <jats:sec> <jats:title /> <jats:p>Human biomonitoring (HBM) is recognized as an important tool to assess the Human exposure to chemicals, contributing to describe trends and patterns of exposure over time and to identify population groups that could be under risk. Natural chemicals as mycotoxins, fungi metabolites that produce toxic effects in humans, are important compounds that could be found in foods usually consumed worldwide in a daily basis. Mycotoxins as aflatoxins (AFTs) are genotoxic, carcinogenic and immunosuppressive compounds. Hepatocellular carcinoma (HCC) is one of their main health toxic effects and is the third leading cause of cancer deaths worldwide. In Portugal, scarce data are available regarding exposure to AFTs and none previous study used HBM data to characterize comprehensively the burden associated to this exposure.</jats:p> <jats:p>In the scope of the National Food, Nutrition, and Physical Activity Survey of the Portuguese General Population (2015-2016), 24h-urine samples from 94 participants were analyzed by liquid chromatography-mass spectrometry (LC-MS/MS) for the simultaneous determination of AFTs (B1, B2, G1, G2, M1). A model was developed to estimate the health impact of the exposure of Portuguese population to aflatoxins, estimating the number of cases of HCC and DALYs attributed to AFTs exposure.</jats:p> <jats:p>AFTs were detected in 12.8% (AFB1), 16.0% (AFB2) and 19.1% (AFM1) of the 24h-urine samples. The estimated number of extra cases of HCC attributed to this exposure ranged from 17 to 65 cases/year; the associated DALYs for the Portuguese population ranged from 284 to 1802 years.</jats:p> <jats:p>The present study generated, for the first time and within a HBM study, reliable data regarding the exposure of the Portuguese population to AFTs. These data were crucial to characterize the health impact associated to AFTs exposure and to support risk managers to establish preventive policy measures that contribute to ensure the public health protection.</jats:p> </jats:sec> <jats:sec> <jats:title>Key messages</jats:title> <jats:p>Portuguese population is exposed to aflatoxins, chemical food contaminants that may be harmful (carcinogenic, immunotoxic, mutagenic, teratogenic, hepatotoxic) to humans. Human biomonitoring studies provide realistic data on internal exposure at individual level, contributing to a more accurate estimation of the burden derived from this exposure.</jats:p> </jats:sec>

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 1