Indoor mite allergens in patients with respiratory allergy living in Porto, Portugal

• Type: Article in International Scientific Journal
• Date: 1996

Authors

Placido, JL (Author) Other; Cuesta, C (Author) Other; Delgado, L (Author) FMUP; daSilva, JPM (Author) Other; Miranda, M (Author) Other; Ventas, P (Author) Other; Vaz, M (Author) Other

Journal

Title: Allergy: European Journal of Allergy and Clinical Immunology

Vol. 51

Pages: 633-639

ISSN: 0105-4538

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 24 Citations

Scopus - 24 Citations

Other information

Authenticus ID: P-001-DQ0

DOI: 10.1111/j.1398-9995.1996.tb04683.x

Abstract (EN): We investigated the levels of mite allergens (Der p 1, Der f 1, Der 2, and Lep d 1) in dust samples from the homes of 59 patients with asthma, 36 sensitized to house-dust mites (HDM) and 23 to grass pollen (controls), Living in Porto, northern Portugal. The relationship between exposure and sensitization to HDM and the influence of housing conditions on mite-allergen levels were also evaluated. Der p 1 (median 9.2 mu g/g) and Der 2 (4.6 mu g/g) were the main allergens, while Der f 1 and Lep d 1 levels were always <1 mu g/g dust and undetectable in 11% and 47% of samples, respectively. All HDM-sensitized asthmatics were exposed to Der p 1 levels >2 mu g/g and their homes contained significantly higher levels of Der p 1 (median 12.5 vs 6.4 mu g/g; P=0.008) and Der 2 (6.2 vs 3.0 mu g/g; P=0.004) when compared to the control group. A significant correlation was observed between the exposure to Der p 1 and the wheal area at skin testing with the Dermatophagoides pteronyssinus (Dp) extract (P=0.01) as well as with serum specific IgE levels to Dp (P=0.03). Patients with higher levels of serum specific IgE (greater than or equal to 17.5 HRU/ml) were also more frequently exposed to Der p 1 levels greater than or equal to 10 mu g/g (P=0.002). Old homes, presence of carpets, and signs of dampness were conditions associated with significantly higher levels of mite allergens. In conclusion, we found high levels of Der p 1 and Der 2 particularly in the homes of HDM-sensitized patients and we confirm the relationship between exposure and sensitization to HDM, assessed by both in vivo and in vitro methods. In addition to a favorable outdoor climate, we found in our region housing conditions propitious to mite growth, suggesting that specific geographic characteristics must also be taken into account for the correct planning of mite-avoidance measures.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7