Gangrene of the fingertips after bleomycin and methotrexate

• Type: Article in International Scientific Journal
• Date: 2000

Authors

Correia, O (Author) Other; Ribas, F (Author) Other; Azevedo, R (Author) Other; Rodrigues, H (Author) Other; Delgado, L (Author) FMUP

Journal

Title: Cutis

Vol. 66

Pages: 271-+

ISSN: 0011-4162

Publisher: Quadrant HealthCom

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 9 Citations

Other information

Authenticus ID: P-000-YT6

Abstract (EN): The increased use of cytostatic drugs, which are sometimes used in combination chemotherapy, may result in new and unusual cutaneous side effects. We describe a 57-year-old man with acral erythrocyanosis progressing to acute digital ischemia and gangrene that developed after combined chemotherapy (bleomycin and methotrexate) used to treat a metastatic squamous cell carcinoma of the hypopharynx. A leukocyloclastic vasculitis was found in both the acute phase and in the amputated fingertips. This supports the well-reported potential of bleomycin to trigger acral vascular toxicity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3