Increased interleukin 10, tumor necrosis factor alpha, and interleukin 6 levels in blister fluid of toxic epidermal necrolysis

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Correia, O (Author) Other; Delgado, L (Author) FMUP; Barbosa, IL (Author) Other; Campilho, F (Author) Other; Fleming Torrinha, J (Author) Other

Journal

Title: Journal of the American Academy of Dermatology

Vol. 47

Pages: 58-62

ISSN: 0190-9622

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 68 Citations

Scopus - 85 Citations

Other information

Authenticus ID: P-000-NWD

DOI: 10.1067/mjd.2002.120473

Abstract (EN): Background: Toxic epidermal necrolysis is a severe, usually drug-induced disease that shares clinical, histologic, and immunologic similarities with the severe forms of cutaneous acute graft-versus-host disease. Objective. Our purpose was to further characterize common immune-inflammatory pathways in these skin disorders by measurement of different cytokines. Methods: Evaluation of serum levels of interleukin 10 (IL-10), tumor necrosis factor alpha, IL-6, and soluble IL-6 receptor in the early phase of both diseases and in blister fluid of toxic epidermal necrolysis. Results: Serum levels of IL-10 and IL-6 were significantly higher in patients with toxic epidermal necrolysis (P = .0001) and acute graft-versus-host disease (P = .001) compared with those of blood donors. We found an increase in IL-6 levels in blister fluid and significantly higher levels of IL-10 (P = .018) and tumor necrosis factor alpha (P = .028) in blister fluid compared with serum in patients with toxic epidermal necrolysis. Conclusion: A similar serum cytokine profile of toxic epidermal necrolysis and acute graft-versus-host disease further emphasizes common immunologic mechanisms. The presence of inflammatory cytokines, IL-6 and tumor necrosis factor alpha, in the blister fluid of patients with toxic epidermal necrolysis is associated with significantly higher levels of IL-10, which through its down-regulatory role, may be involved in limitation of the disease extension.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5