A Tailor-Made Protocol to Synthesize Yolk-Shell Graphene-Based Magnetic Nanoparticles for Nanomedicine

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Raquel O. Rodrigues (Author) Other; Giovanni Baldi (Author) Other; Saer Doumett (Author) Other; Juan Gallo (Author) Other; Manuel Bañobre-López (Author) Other; Goran Dra¸ic (Author) Other; Ricardo C. Calhelha (Author) Other; Isabel C. F. R. Ferreira (Author) Other; Rui Lima (Author) Other; Adrián M. T. Silva (Author) FEUP; Helder T. Gomes (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: C-JOURNAL OF CARBON RESEARCH

Vol. 4 No. 4

Pages: 1-15

ISSN: 2311-5629

Indexing

ISI Web of Knowledge - 1 Citation

Other information

Authenticus ID: P-00R-31D

DOI: 10.3390/c4040055

Abstract (EN): A simple tailor-made protocol to synthesize graphene-based magnetic nanoparticles (GbMNPs) for nanomedicine is herein reported. Different GbMNPs with very distinctive physicochemical and toxicological properties were synthesized by adjusting the number of carbon precursors in the coating of superparamagnetic iron oxide nanoparticles. In vitro tests show the ability to use these GbMNPs as intelligent and on-demand drug nanocarrier systems for drug delivery, exhibiting the following features: good colloidal stability, good loading capacity of the chemotherapeutic drug doxorubicin, high pH-controlled release of the encapsulated drug (targeting tumour acidic pH conditions), superparamagnetic behaviour and biocompatibility. Due to their combined properties (i.e., physicochemical, magnetic, and biocompatibility), GbMNPs show high potentiality to be combined with other biomedical techniques, such as magnetic hyperthermia, which can represent an enhancement in the treatment of cancer.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15