Silymarin antiproliferative and apoptotic effects: Insights into its clinical impact in various types of cancer

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Célia Fortuna Rodrigues (Author) FEUP; Tahereh Hosseinabadi (Author) Other; Zahra Lorigooini (Author) Other; Maryam Tabarzad (Author) Other; Bahare Salehi (Author) Other; Natália Martins (Author) Other; Javad Sharifi-Rad (Author) Other

Journal

Title: Phytotherapy Research

Vol. 33 No. 11

Pages: 2849-2861

ISSN: 0951-418X

Publisher: Wiley-Blackwell

Indexing

ISI Web of Science

Scopus

Other information

DOI: 10.1002/ptr.6470

Abstract (EN): Silymarin is a complex extract isolated from the plant Silybum marianum, widely known for its prominent antioxidant and hepatoprotective effects, although increasing evidences have reported extraordinary antiproliferative and apoptotic abilities. As a result, several signaling pathways involved in cell cycle control, cell proliferation, and cell death have been deconvoluted as critical mechanisms. In this regard, cyclin and cyclin-dependent pathways have been the most studied ones. Following that, apoptotic pathways, such as p53, Akt, STAT-3, Ras, and caspases pathways, have been extensively studied, although other mechanisms involved in inflammation and angiogenesis have also been highlighted as silymarin-likely targets in cancer therapy. Therefore, the main challenge of this review is to discuss the diverse molecular mechanisms for silymarin antiproliferative and apoptotic effects; most of them largely studied in various types of cancers so far. Clinical trials and combination therapies related to silymarin application in cancer prevention and treatment are presented as well.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13