Modulation of Iron Metabolism in Response to Infection: Twists for All Tastes

• Type: Another Publication in an International Scientific Journal
• Date: 2018

Authors

Gomes, AC (Author) Other; Moreira, AC (Author) Other; Mesquita, G (Author) Other; Gomes, MS (Author) ICBAS

Journal

Title: Pharmaceuticals

Vol. 11

Final page: 84

ISSN: 1424-8247

Publisher: MDPI

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 12 Citations

Other information

Authenticus ID: P-00P-NVH

DOI: 10.3390/ph11030084

Abstract (EN): Iron is an essential nutrient for almost all living organisms, but is not easily made available. Hosts and pathogens engage in a fight for the metal during an infection, leading to major alterations in the host's iron metabolism. Important pathological consequences can emerge from the mentioned interaction, including anemia. Several recent reports have highlighted the alterations in iron metabolism caused by different types of infection, and several possible therapeutic strategies emerge, based on the targeting of the host's iron metabolism. Here, we review the most recent literature on iron metabolism alterations that are induced by infection, the consequent development of anemia, and the potential therapeutic approaches to modulate iron metabolism in order to correct iron-related pathologies and control the ongoing infection.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 17