Potential Use of Chemoprotectants against the Toxic Effects of Cyanotoxins: A Review

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Guzman Guillen, R (Author) Other; Puerto, M (Author) Other; Gutierrez Praena, D (Author) Other; Prieto, AI (Author) Other; Pichardo, S (Author) Other; Jos, A (Author) Other; Alexandre Campos (Author) FCUP; Vitor Vasconcelos (Author) FCUP; Camean, AM (Author) Other

Journal

Title: Toxins

Vol. 9

Final page: 175

ISSN: 2072-6651

Publisher: MDPI

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 8 Citations

Other information

Authenticus ID: P-00M-VX0

DOI: 10.3390/toxins9060175

Abstract (EN): Cyanobacterial toxins, particularly microcystins (MCs) and cylindrospermopsin (CYN), are responsible for toxic effects in humans and wildlife. In order to counteract or prevent their toxicity, various strategies have been followed, such as the potential application of chemoprotectants. A review of the main substances evaluated for this aim, as well as the doses and their influence on cyanotoxin-induced toxicity, has been performed. A search of the literature shows that research on MCs is much more abundant than research on CYN. Among chemoprotectants, antioxidant compounds are the most extensively studied, probably because it is well known that oxidative stress is one of the toxic mechanisms common to both toxins. In this group, vitamin E seems to have the strongest protectant effect for both cyanotoxins. Transport inhibitors have also been studied in the case of MCs, as CYN cellular uptake is not yet fully elucidated. Further research is needed because systematic studies are lacking. Moreover, more realistic exposure scenarios, including cyanotoxin mixtures and the concomitant use of chemoprotectants, should be considered.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 36