Rational Design of Multi-Target Estrogen Receptors ER alpha and ER beta by QSAR Approaches

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Zhao, Q (Author) Other; Lu, YX (Author) Other; Zhao, Y (Author) Other; Li, RC (Author) Other; Luan, F (Author) Other; Natalia N D S Cordeiro (Author) FCUP

Journal

Title: Current Drug Targets

Vol. 18

Pages: 576-591

ISSN: 1389-4501

Publisher: Bentham Science

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 3 Citations

Other information

Authenticus ID: P-00M-E87

DOI: 10.2174/1389450117666160401125542

Abstract (EN): Estrogens play a crucial role in the growth, development, and homeostasis of various target tissues, their biological effects being mediated by the estrogen receptor (ER). In order to get a better understanding of the structural features of the modulators associated with the binding to ER, this paper provides an overview of the Quantitative Structure-Activity (QSAR) studies performed so far for estimating or predicting the activity of different ligands towards its two known subtypes (ER alpha and ER beta). Recent progresses in the application of these modeling studies are additionally pointed out. Finally, ongoing challenges that may lead to new and exciting directions for QSAR modeling studies in this field are discussed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 16