Ecotoxicological evaluation of gilthead seabream (Sparus aurata) exposed to the antibiotic oxytetracycline using a multibiomarker approach

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Rodrigues, S (Author) Other; Antunes, SC (Author) FCUP; Correia, AT (Author) Other; Nunes, B (Author) Other

Journal

Title: Marine Environmental Research

Vol. 141

Pages: 233-246

ISSN: 0141-1136

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 14 Citations

Scopus - 15 Citations

Other information

Authenticus ID: P-00P-N30

DOI: 10.1016/j.marenvres.2018.09.009

Abstract (EN): Oxytetracycline (OTC) is an antibiotic widely used in human and veterinary medicines. Since the primary toxicity occurs mainly at molecular/biochemical levels, the study of different biological responses corresponds to a sensitive and crucial approach. The aim of the present study was to assess the toxic effects of OTC in gilthead seabream (Spares aurata) through the use of multibiomarkers and elucidate about the possible toxicological mechanisms involved. S. aurata were acutely (96 h: 0.04-400 mu g/L) and chronically (28 days: 0.0004-4 mu g/L) exposed to OTC. Detoxification, antioxidant defense, lipid peroxidation, genotoxicity, neurotransmission and energy metabolism biomarkers were evaluated. OTC impaired the detoxification pathways and caused peroxidative damage and genotoxicity. The relevance of the here-obtained data is high, since significant effects were recorded for levels already reported to occur in the wild, meaning that environmentally-exposed marine organisms (including those cultured at fish farms) are not completely exempt of risks posed by OTC.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14