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Delphinidin-3-O-glucoside inhibits angiogenesis via VEGFR2 downregulation and migration through actin disruption

Title
Delphinidin-3-O-glucoside inhibits angiogenesis via VEGFR2 downregulation and migration through actin disruption
Type
Article in International Scientific Journal
Year
2019
Authors
Faria, MA
(Author)
Other
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Sousa, JB
(Author)
Other
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Vojtek, M
(Author)
Other
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Goncalves Monteiro, S
(Author)
Other
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Suliburska, J
(Author)
Other
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Diniz, C
(Author)
FFUP
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Ferreira, Isabel
(Author)
FFUP
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Journal
Vol. 54
Pages: 393-402
ISSN: 1756-4646
Publisher: Elsevier
Scientific classification
CORDIS: Health sciences
FOS: Medical and Health sciences
Other information
Authenticus ID: P-00Q-DJW
Abstract (EN): Excessive angiogenesis favours cancer development, allowing cancer invasion. Polyphenols are promising chemopreventive agents, although data gather so far in respect of anthocyanins, namely cyanidin-3-O-glucoside and delphinidin-3-O-glucoside (DG) and respective aglycones are scarce. The capability of these compounds to prevent tumour progression by inhibiting angiogenesis/cell migration/proliferation was studied in: (i) chicken embryo chorioallantoic membrane assay; (ii) MDA-MB-231/MCF-12A cells to study proliferation and vascular endothelial growth factor receptor-2 (VEGFR-2) expression and cytoskeleton dynamics; (iii) in vitro assay to evaluate gastrointestinal digestion. The studied compounds promoted alterations on actin re/disassembly to form protrusions/stress fibres, evidencing capability to disrupt actin cytoskeleton dynamics and inhibiting angiogenesis, at least in part, by VEGFR-2 downregulation, with DG presenting the higher effect. Anthocyanin evidenced selectivity towards cancer cells by eliciting cytotoxicity on MDA-MB-231 cells and having a slight effect on healthy cells. Thus, DG evidenced the most promising profile as dietary supplement to achieve the biological desired effects.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 10
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