Cough Reflex Testing With Inhaled Capsaicin and TRPV1 Activation in Asthma and Comorbid Conditions

• Type: Another Publication in an International Scientific Journal
• Date: 2013

Authors

Couto, M (Author) FMUP; de Diego, A (Author) Other; Perpina, M (Author) Other; Delgado, L (Author) FMUP; Moreira, André (Author) FMUP

Journal

Title: Journal of Investigational Allergology and Clinical Immunology

Vol. 23

Pages: 289-301

ISSN: 1018-9068

Publisher: Esmon Publicidad S.A.

Indexing

ISI Web of Knowledge - 24 Citations

Scopus - 26 Citations

Other information

Authenticus ID: P-006-FSY

Abstract (EN): A high parasympathetic tone leading to bronchoconstriction and neurogenic inflammation is thought to have a major role in the pathogenesis of asthma. Transient receptor potential vanilloid 1 (TRPV1) is the hub of almost all neuronal inflammatory signaling pathways. A critical determinant of neurogenic inflammation, TRPV1 functions as a sensor for detecting irritants in the lung by transmitting noxious stimuli to the central nervous system and inducing the release of a variety of proinflammatory neuropeptides at the peripheral terminals. Challenge with inhaled capsaicin, an exogenous agonist of TRPV1, has been used to measure the sensitivity of the cough reflex. However, inhalation of capsaicin is also associated with parasympathetic bronchoconstriction, mucus hypersecretion, vasodilatation, and the sensation of dyspnea. Therefore, inhaled capsaicin challenge is expected to have other potential applications in asthma and comorbid conditions, such as rhinitis and gastroesophageal reflux disease, both of which produce cough. Capsaicin challenge has established itself as a useful objective method for evaluating airway hypersensitivity; however, it is potentially valuable in many other situations, which will be reviewed in this paper.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13