Dermatological and ophthalmological sequels in toxic epidermal necrolysis

• Type: Article in International Scientific Journal
• Date: 2003

Authors

magina, s (Author) FMUP; Carmen Silva (Author) FMUP; Leal, V (Author) Other; Palmares, J (Author) Other; Mesquita Guimaraes, J (Author) Other

Journal

Title: Dermatology

Vol. 207

Pages: 33-36

ISSN: 1018-8665

Publisher: Karger

Indexing

ISI Web of Knowledge - 54 Citations

Scopus - 78 Citations

Other information

Authenticus ID: P-000-JG3

DOI: 10.1159/000070938

Abstract (EN): Background: Toxic epidermal necrolysis (TEN) is a rare, drug-induced disease characterized by epidermal detachment and mucosal involvement. After an acute period, potentially disabling cutaneous and ocular sequels may appear. Although long-term complications are not rare, only few outcome studies are published. Objective: To evaluate the incidence of dermatological and ophthalmological sequels following TEN, to describe its clinical aspects and correlation with acute involvement. Patients and Methods: Eight patients surviving to TEN were submitted to dermatological and ophthalmological observation ranging from 0.5 to 8 years after hospitalization. Cutaneous and ocular involvement, during the acute phase, was retrospectively analysed. Results: Dermatological sequels were observed in 6 patients (75%) corresponding to those with more extensive skin involvement in the acute phase. The most frequent complications were cutaneous dyschromia (62.5%) and nail dystrophies (37.5%). Six patients (75%) had ocular complications with tarsal conjunctiva keratinization in 5 (62.5%) and keratoconjunctivitis sicca in 4 of them (50%). Trichiasis, corneal neovascularization and symblepharon were observed in 1 case. There was no correlation between the severity of acute ocular involvement and long-term complications. Conclusion: Following TEN, most patients have dermatological and ophthalmological sequels that persist for several years. Copyright (C) 2003 S. Karger AG, Basel.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4