EGFR exon mutation distribution and outcome in non-small-cell lung cancer: a Portuguese retrospective study

• Type: Article in International Scientific Journal
• Date: 2012

Authors

de Mello, RA (Author) Other; F.M. Andrade Pires (Author) FEUP; Marques, DS (Author) Other; Oliveira, J (Author) Other; Rodrigues, A (Author) Other; Soares, M (Author) Other; Azevedo, I (Author) Other; Peixoto, A (Author) Other; Santos, C (Author) Other; Pinto, C (Author) Other; Hespanhol V (Author) FMUP; Manuel R Teixeira (Author) ICBAS; Amaro, T (Author) Other; Queiroga, H (Author) FMUP; Araujo, A (Author) Other

Journal

Title: Tumor Biology

Vol. 33

Pages: 2061-2068

ISSN: 1010-4283

Publisher: SAGE

Indexing

ISI Web of Knowledge - 24 Citations

Scopus - 27 Citations

Other information

Authenticus ID: P-002-31M

DOI: 10.1007/s13277-012-0465-5

Abstract (EN): Epidermal growth factor receptor (EGFR) mutations play a predictive role in advanced stages of non-small-cell lung cancer (NSCLC) patients. We conducted this study in order to assess EGFR status in a Portuguese population and its role in NSCLC patients' outcomes. Patients were submitted to EGFR assessment by high-resolution melting and/or direct sequencing. Kaplan-Meier curve was used to assess overall survival and progression-free survival (PFS). Two hundred forty eight out of 322 participants were assessed for EGFR status. Forty-two patients (16.9 %) presented EGFR-mutated status: one patient (2.4 %) presented exon 18; 21 patients (50 %), exon 19; one patient (2.4 %), exon 20; and 18 patients (45.2 %), exon 21 mutations, p < 0.001. PFS was not assessed (n.a.) for patient with exon 18 mutation, and for the other patients with mutations, it was 7 months (3.96-10.03) (exon 19), < 1 month (exon 20), and 7 months (0-14.2) (exon 21) (p = 0.027). Overall survival (OS) was 11 months (exon 18), 11 months (1-18) (exon 19), 1 month (exon 20), and 7.5 months (2-70) (exon 21) (p = n.a). This study suggests that the EGFR mutation is herein observed in a higher proportion than expected for a Caucasian population, and OS is a little less than that published in the literature.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8