Synthesis of (E)-3-Styrylquinolin-4(1H)-ones in Water by Ohmic Heating: a Comparison with Other Methodologies

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Pinto, J (Author) Other; Silva, VLM (Author) Other; Luis M N B F Santos (Author) FCUP; Silva, AMS (Author) Other

Journal

Title: European Journal of Organic Chemistry

Vol. 2016

Pages: 2888-2896

ISSN: 1434-193X

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 10 Citations

Other information

Authenticus ID: P-00K-PQJ

DOI: 10.1002/ejoc.201600150

Abstract (EN): Ohmic heating offers a very efficient way to perform organic reactions in aqueous media. Potentially bioactive (E)-3-styrylquinolin-4(1H)-ones were synthesized by the Heck reaction of 3-iodo-1-methylquinolin-4(1H)-one with styrenes in water and with ohmic heating. Pd(OAc)(2) was used as catalyst, and tetrabutylammonium bromide was used as phase-transfer catalyst in the presence of an inorganic base. Comparison with other established procedures highlight the benefits of this new methodology.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9