The Origin and Diversity of Cpt1 Genes in Vertebrate Species

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Lopes Marques, M (Author) Other; Delgado, ILS (Author) Other; Ruivo, R (Author) Other; Torres, Y (Author) Other; Sainath, SB (Author) Other; rocha, e (Author) ICBAS; Cunha, I (Author) Other; Santos, MM (Author) FCUP; Filipe F C Castro (Author) FCUP

Journal

Title: PLoS ONE

Vol. 10

ISSN: 1932-6203

Publisher: Public Library of Science

Indexing

ISI Web of Knowledge - 18 Citations

Scopus - 21 Citations

Other information

Authenticus ID: P-00G-R7S

DOI: 10.1371/journal.pone.0138447

Abstract (EN): The Carnitine palmitoyltransferase I (Cpt1) gene family plays a crucial role in energy homeostasis since it is required for the occurrence of fatty acid beta-oxidation in the mitochondria. The exact gene repertoire in different vertebrate lineages is variable. Presently, four genes are documented: Cpt1a, also known as Cpt1a1, Cpt1a2; Cpt1b and Cpt1c. The later is considered a mammalian innovation resulting from a gene duplication event in the ancestor of mammals, after the divergence of sauropsids. In contrast, Cpt1a2 has been found exclusively in teleosts. Here, we reassess the overall evolutionary relationships of Cpt1 genes using a combination of approaches, including the survey of the gene repertoire in basal gnathostome lineages. Through molecular phylogenetics and synteny studies, we find that Cpt1c is most likely a rapidly evolving orthologue of Cpt1a2. Thus, Cpt1c is present in other lineages such as cartilaginous fish, reptiles, amphibians and the coelacanth. We show that genome duplications (2R) and variable rates of sequence evolution contribute to the history of Cpt1 genes in vertebrates. Finally, we propose that loss of Cpt1b is the likely cause for the unusual energy metabolism of elasmobranch.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14