Cloning and functional characterization of a retinoid X receptor orthologue in Platynereis dumerilii: An evolutionary and toxicological perspective

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Andre, A (Author) Other; Ruivo, R (Author) Other; Capitao, A (Author) Other; Froufe, E (Author) Other; Pascoa, I (Author) Other; Filipe F C Castro (Author) FCUP; Santos, MM (Author) FCUP

Journal

Title: Chemosphere

Vol. 182

Pages: 753-761

ISSN: 0045-6535

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 14 Citations

Scopus - 15 Citations

Other information

Authenticus ID: P-00N-XRP

DOI: 10.1016/j.chemosphere.2017.05.064

Abstract (EN): In the present work we provide the first isolation and functional characterization of a RXR orthologue in an annelid species, the Platynereis dumerilii. Using an in vitro luciferase reporter assay we evaluated the annelid receptor ability to respond to ligand 9-cis-retinoic acid, TBT and TPT. Our results show that the annelid RXR responds to 9-cis-retinoic acid and to the organotins by activating reporter gene transcription. The findings suggest a conserved mode of action of the receptor in response to a common signaling molecule and modulation by organotin compounds between vertebrates and Lophotrochozoans.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9